Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

Northcott, PA; Shih, DJH; Peacock, J; Garzia, L; Sorana Morrissy, A; Zichner, T; Stütz, AM; Korshunov, A; Reimand, J; Schumacher, SE; Beroukhim, R; Ellison, DW; Marshall, CR; Lionel, AC; Mack, S; Dubuc, A; Yao, Y; Ramaswamy, V; Luu, B; Rolider, A; Cavalli, FMG; Wang, X; Remke, M; Wu, X; Chiu, RYB; Chu, A; Chuah, E; Corbett, RD; Hoad, GR; Jackman, SD; Li, Y; Lo, A; Mungall, KL; Ming, Nip K; Qian, JQ; Raymond, AGJ; Thiessen, N; Varhol, RJ; Birol, I; Moore, RA; Mungall, AJ; Holt, R; Kawauchi, D; Roussel, MF; Kool, M; Jones, DTW; Witt, H; Fernandez-L A; Kenney, AM; Wechsler-Reya, RJ; Dirks, P; Aviv, T; Grajkowska, WA; Perek-Polnik, M; Haberler, CC; Delattre, O; Reynaud, SS; Doz, FF; Pernet-Fattet, SS; Cho, B-K; Kim, S-K; Wang, K-C; Scheurlen, W; Eberhart, CG; Fèvre-Montange, M; Jouvet, A; Pollack, IF; Fan, X; Muraszko, KM; Yancey, Gillespie G; Di Rocco, C; Massimi, L; Michiels, EMC; Kloosterhof, NK; French, PJ; Kros, JM; Olson, JM; Ellenbogen, RG; Zitterbart, K; Kren, L; Thompson, RC; Cooper, MK; Lach, B; McLendon, RE; Bigner, DD; Fontebasso, A; Albrecht, S; Jabado, N; Lindsey, JC; Bailey, S; Gupta, N; Weiss, WA; Bognár, László; Klekner, Álmos; Van, Meter TE; Kumabe, T; Tominaga, T; Elbabaa, SK; Leonard, JR; Rubin, JB; Liau, LM; Van, Meir EG; Fouladi, M; Nakamura, H; Cinalli, G; Garami, Miklós; Hauser, Péter; Saad, AG; Iolascon, A; Jung, S; Carlotti, CG; Vibhakar, R; Shin, Ra Y; Robinson, S; Zollo, M; Faria, CC; Chan, JAD; Levy, ML; Sorensen, PHB; Meyerson, M; Pomeroy, SL; Cho, Y-J; Bader, GD; Tabori, U; Hawkins, CE; Bouffet, E; Scherer, SW; Rutka, JT; Malkin, D; Clifford, SC; Jones, SJM; Korbel, JO; Pfister, SM; Marra, MA; Taylor, MD

Journal article

NATURE vol.:488, issue.:7409, p.:49-56.

ISSN: 0028-0836; 1476-4687

URI: http://repo.lib.semmelweis.hu//handle/123456789/4119
https://doi.org/10.1038/nature11327

xmlui.dri2xhtml.METS-1.0.item-mtmtid: 2034612

WoS ID: 000307010700030

PubMed ID: 22832581

Date: 2012

Abstract:

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched. The most common region of focal copy number gain is a tandem duplication of SNCAIP, a gene associated with Parkinson's disease, which is exquisitely restricted to Group 4α. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy.

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