Show simple item record Benkovits, Judit Magyarosi S Pulay, Attila József Makkos Z Egerhazi A Balogh N Almos P Liko I Schizobank Consortium H Nemeth G; Molnár, Mária Judit Nagy L Réthelyi, János 2017-03-29T08:43:37Z 2017-03-29T08:43:37Z 2016
dc.identifier.citation pagination=181-187; journalVolume=18; journalIssueNumber=4; journalTitle=NEUROPSYCHOPHARMACOLOGIA HUNGARICA;
dc.description.abstract Schizophrenia is a chronic, debilitating psychiatric disorder characterized by heterogeneous clinical symptoms. Although the pathogenesis of this disorder is poorly understood, several lines of evidence support the role of both common and rare genetic variants in the etiology of schizophrenia. Common variants, single nucleotide polymorphisms can be investigated by candidate gene association studies or genome-wide association studies, while rare variants, single nucleotide variants are assessable by means of candidate gene resequencing or whole-exome and genome sequencing using next generation sequencing. In this study we investigated polymorphisms of 7 candidate genes in a Hungarian schizophrenia cohort. Candidate genes were chosen on the basis of previous results and biological plausibility. 390 patients were recruited in 5 centers in the framework of the Hungarian SCHIZOBANK Consortium, the schizophrenia sample was contrasted to 1069 healthy control individuals. In this sample SNPs of DDR1 and DRD2 genes demonstrated significant association with schizophrenia. The role of DDR1 and DRD2 genes in the etiology of schizophrenia warrant further investigation, based on their genomic localization and biological functions.
dc.relation.ispartof urn:issn:1419-8711
dc.title CNTF, COMT, DDR1, DISC1, DRD2, DRD3 es DTNBP1 kandidáns gének vizsgálata szkizofréniában: eredmények a Magyar SCHIZOBANK Konzorcium vizsgálataból
dc.type Journal Article 2017-03-27T07:55:25Z
dc.language.rfc3066 hu
dc.identifier.mtmt 3204777
dc.identifier.pubmed 28259861
dc.contributor.department SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika
dc.contributor.department SE/AOK/I/Genomikai Medicina és Ritka Betegségek Intézete
dc.contributor.institution Semmelweis Egyetem

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