dc.contributor.author |
Fischer K |
|
dc.contributor.author |
McDannold NJ |
|
dc.contributor.author |
Zhang Y |
|
dc.contributor.author |
Kardos, Magdolna |
|
dc.contributor.author |
Szabó, András |
|
dc.contributor.author |
Szabó A |
|
dc.contributor.author |
Reusz, György |
|
dc.contributor.author |
Jolesz, Ferenc |
|
dc.date.accessioned |
2017-10-06T07:12:47Z |
|
dc.date.available |
2017-10-06T07:12:47Z |
|
dc.date.issued |
2009 |
|
dc.identifier |
73949134550 |
|
dc.identifier.citation |
pagination=697-705;
journalVolume=253;
journalIssueNumber=3;
journalTitle=RADIOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/4219 |
|
dc.identifier.uri |
doi:10.1148/radiol.2532082100 |
|
dc.description.abstract |
PURPOSE: To determine if focused ultrasonography (US) combined with a diagnostic microbubble-based US contrast agent can be used to modulate glomerular ultrafiltration and size selectivity. MATERIALS AND METHODS: The experiments were approved by the animal care committee. The left kidney of 17 healthy rabbits was sonicated by using a 260-kHz focused US transducer in the presence of a microbubble-based US contrast agent. The right kidney served as the control. Three acoustic power levels were applied: 0.4 W (six rabbits), 0.9 W (six rabbits), and 1.7 W (five rabbits). Three rabbits were not treated with focused US and served as control animals. The authors evaluated changes in glomerular size selectivity by measuring the clearance rates of 3000- and 70,000-Da fluorescence-neutral dextrans. The creatinine clearance was calculated for estimation of the glomerular filtration rate. The urinary protein-creatinine ratio was monitored during the experiments. The authors assessed tubular function by evaluating the fractional sodium excretion, tubular reabsorption of phosphate, and gamma-glutamyltransferase-creatinine ratio. Whole-kidney histologic analysis was performed. For each measurement, the values obtained before and after sonication were compared by using the paired t test. RESULTS: Significant (P < .05) increases in the relative (ratio of treated kidney value/nontreated kidney value) clearance of small- and large-molecule agents and the urine flow rates that resulted from the focused US treatments were observed. Overall, 1.23-, 1.23-, 1.61-, and 1.47-fold enhancement of creatinine clearance, 3000-Da dextran clearance, 70 000-Da dextran clearance, and urine flow rate, respectively, were observed. Focal tubular hemorrhage and transient functional tubular alterations were observed at only the highest (1.7-W) acoustic power level tested. CONCLUSION: Glomerular ultrafiltration and size selectivity can be temporarily modified with simultaneous application of US and microbubbles. This method could offer new opportunities for treatment of renal disease. |
|
dc.relation.ispartof |
urn:issn:0033-8419 |
|
dc.title |
Renal ultrafiltration changes induced by focused US |
|
dc.type |
Journal Article |
|
dc.date.updated |
2017-04-03T09:46:05Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1778041 |
|
dc.identifier.wos |
000272247300016 |
|
dc.identifier.pubmed |
19703861 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/I/II. Sz. Patológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|