Show simple item record Sziksz, Erna Kozma, Gergely Tibor Komlósi, Zsolt Pállinger, Éva Kardos, Magdolna Szebeni, Beáta Losonczy, György Falus, András Szabó, András Tulassay, Tivadar Vannay, Ádám 2018-02-22T14:01:36Z 2018-02-22T14:01:36Z 2010
dc.identifier 77955868519
dc.identifier.citation pagination=420-430; journalVolume=36; journalIssueNumber=7; journalTitle=EXPERIMENTAL LUNG RESEARCH;
dc.identifier.uri doi:10.3109/01902141003767955
dc.description.abstract Histamine and vascular endothelial growth factor (VEGF) have been implicated in the pathogenesis of allergic asthma; they enhance inflammation, vascular permeability, and mucus secretion. Histamine was suggested to alter the level of VEGF via the H2 receptors. Here the authors have applied histidine decarboxylase gene-targeted (HDC-/-) mice, lacking histamine, to investigate the effect of histamine deficiency on VEGF expression in an animal model of asthma. HDC-/- and wild-type (WT) mice were sensitized and challenged with ovalbumin (OVA). VEGF mRNA expression and protein level were determined in the lung. Number of VEGF-positive immune cells of bronchoalveolar lavage (BAL) and their intracellular VEGF content were measured by flow cytometry. VEGF protein level in the lung and in the BAL cells was increased in OVA treated (HDCova-/- as well as in WTova) animals compared to their controls. However, there was no difference in the VEGF levels between HDC-/- or WT animals, either in the lung or in the BAL cells. In conclusion, increased VEGF production of the lung or BAL immune cells can be induced by allergen provocation independently from the genetic background of the animals. These data suggest that VEGF-mediated allergic processes can persist in the absence of histamine.
dc.relation.ispartof urn:issn:0190-2148
dc.title Increased synthesis of vascular endothelial growth factor in allergic airway inflammation in histidine decarboxylase knockout (HDC-/-) mice
dc.type Journal Article 2017-04-03T12:50:30Z
dc.language.rfc3066 en
dc.identifier.mtmt 1384867
dc.identifier.wos 000280966100005
dc.identifier.pubmed 20715981
dc.contributor.department SE/AOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport
dc.contributor.department SE/AOK/K/Pulmonológiai Klinika
dc.contributor.department SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.department MTA TKI/MTA-SE Gyulladásbiológiai és Immungenomikai Kutatócsoport (2006-ig: MTA-SE Molekuláris Immunológiai Kutatócsoport) [2009.12.31]
dc.contributor.institution Semmelweis Egyetem

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