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dc.contributor.author Szász, Attila Marcell
dc.contributor.author Ács, Balázs
dc.contributor.author Ágoston, Emese
dc.contributor.author Sztupinszki, Zsófia
dc.contributor.author Tőkés, Anna-Mária
dc.contributor.author Szittya Liliána
dc.contributor.author Székely, Borbála
dc.contributor.author Szendrői, Miklós
dc.contributor.author Li Quiyuan
dc.contributor.author Harsányi, László
dc.contributor.author Tímár, József
dc.contributor.author Szállási Zoltán
dc.contributor.author Swanton Charles
dc.contributor.author Győrffy, Balázs
dc.contributor.author Kulka, Janina
dc.date.accessioned 2015-11-02T12:59:25Z
dc.date.available 2015-11-02T12:59:25Z
dc.date.issued 2013
dc.identifier 84876267460
dc.identifier.citation pagination=627-632; journalVolume=154; journalIssueNumber=16; journalTitle=ORVOSI HETILAP;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/423
dc.identifier.uri doi:10.1556/OH.2013.29590
dc.description.abstract Background: Grade 2 breast carcinomas do not form a uniform prognostic group. Aim: To extend the number of patients and the investigated genes of a previously identified prognostic signature described by the authors that reflect chromosomal instability in order to refine characterization of grade 2 breast cancers and identify driver genes. Methods: Using publicly available databases, the authors selected 9 target and 3 housekeeping genes that are capable to divide grade 2 breast carcinomas into prognostic groups. Gene expression was investigated by polymerase chain reaction in 249 formalin-fixed, paraffin-embedded breast tumors. The results were correlated with relapse-free survival. Results: Histologically grade 2 carcinomas were split into good and a poor prognosis groups. Centroid-based ranking showed that 3 genes, FOXM1, TOP2A and CLDN4 were able to separate the good and poor prognostic groups of grade 2 breast carcinomas. Conclusion: Using appropriately selected control genes, a limited set of genes is able to split prognostic groups of breast carcinomas independently from their grade.
dc.relation.ispartof urn:issn:0030-6002
dc.title Egyszerűsített, alacsony költségű génexpressziós teszt az emlődaganatos betegségek kimenetelének előrejelzésére rutin patológiai blokkok felhasználásával
dc.type Journal Article
dc.date.updated 2014-11-06T10:42:50Z
dc.language.rfc3066 hu
dc.identifier.mtmt 2286072
dc.contributor.department SE/ÁOK/K/I. Sz. Sebészeti Klinika
dc.contributor.department SE/ÁOK/I/IISZPI/MTA-SE Molekuláris Onkológia Kutatócsoport
dc.contributor.department SE/ÁOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.department SE/AOK/K/Ortopédiai Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Szász A. Marcell, Ács Balázs, Ágoston Emese szerzők egyenlő mértékben járultak hozzá a közleményhez.


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