Show simple item record Szász, Attila Marcell Ács, Balázs Ágoston, Emese Sztupinszki, Zsófia Tőkés, Anna-Mária Szittya Liliána Székely, Borbála Szendrői, Miklós Li Quiyuan Harsányi, László Tímár, József Szállási Zoltán Swanton Charles Győrffy, Balázs Kulka, Janina 2015-11-02T12:59:25Z 2015-11-02T12:59:25Z 2013
dc.identifier 84876267460
dc.identifier.citation pagination=627-632; journalVolume=154; journalIssueNumber=16; journalTitle=ORVOSI HETILAP;
dc.identifier.uri doi:10.1556/OH.2013.29590
dc.description.abstract Background: Grade 2 breast carcinomas do not form a uniform prognostic group. Aim: To extend the number of patients and the investigated genes of a previously identified prognostic signature described by the authors that reflect chromosomal instability in order to refine characterization of grade 2 breast cancers and identify driver genes. Methods: Using publicly available databases, the authors selected 9 target and 3 housekeeping genes that are capable to divide grade 2 breast carcinomas into prognostic groups. Gene expression was investigated by polymerase chain reaction in 249 formalin-fixed, paraffin-embedded breast tumors. The results were correlated with relapse-free survival. Results: Histologically grade 2 carcinomas were split into good and a poor prognosis groups. Centroid-based ranking showed that 3 genes, FOXM1, TOP2A and CLDN4 were able to separate the good and poor prognostic groups of grade 2 breast carcinomas. Conclusion: Using appropriately selected control genes, a limited set of genes is able to split prognostic groups of breast carcinomas independently from their grade.
dc.relation.ispartof urn:issn:0030-6002
dc.title Egyszerűsített, alacsony költségű génexpressziós teszt az emlődaganatos betegségek kimenetelének előrejelzésére rutin patológiai blokkok felhasználásával
dc.type Journal Article 2014-11-06T10:42:50Z
dc.language.rfc3066 hu
dc.identifier.mtmt 2286072
dc.contributor.department SE/ÁOK/K/I. Sz. Sebészeti Klinika
dc.contributor.department SE/ÁOK/I/IISZPI/MTA-SE Molekuláris Onkológia Kutatócsoport
dc.contributor.department SE/ÁOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.department SE/AOK/K/Ortopédiai Klinika
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Szász A. Marcell, Ács Balázs, Ágoston Emese szerzők egyenlő mértékben járultak hozzá a közleményhez.

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