Show simple item record Brown D Smeets D Székely, Borbála Larsimont D Szász, Attila Marcell Adnet PY Rothe F Rouas G Nagy ZI Farago Z Tőkés, Anna-Mária Dank, Magdolna Szentmártoni, Gyöngyvér Udvarhelyi N Zoppoli G Pusztai L Piccart M Kulka, Janina Lambrechts D Sotiriou C Desmedt C 2017-05-22T06:20:35Z 2017-05-22T06:20:35Z 2017
dc.identifier.citation pagination=14944, pages 12; journalVolume=8; journalTitle=NATURE COMMUNICATIONS;
dc.identifier.uri doi:10.1038/ncomms14944
dc.description.abstract Several studies using genome-wide molecular techniques have reported various degrees of genetic heterogeneity between primary tumours and their distant metastases. However, it has been difficult to discern patterns of dissemination owing to the limited number of patients and available metastases. Here, we use phylogenetic techniques on data generated using whole-exome sequencing and copy number profiling of primary and multiple-matched metastatic tumours from ten autopsied patients to infer the evolutionary history of breast cancer progression. We observed two modes of disease progression. In some patients, all distant metastases cluster on a branch separate from their primary lesion. Clonal frequency analyses of somatic mutations show that the metastases have a monoclonal origin and descend from a common 'metastatic precursor'. Alternatively, multiple metastatic lesions are seeded from different clones present within the primary tumour. We further show that a metastasis can be horizontally cross-seeded. These findings provide insights into breast cancer dissemination.
dc.relation.ispartof urn:issn:2041-1723
dc.title Phylogenetic analysis of metastatic progression in breast cancer using somatic mutations and copy number aberrations.
dc.type Journal Article 2017-05-02T08:41:04Z
dc.language.rfc3066 en
dc.identifier.mtmt 3215567
dc.identifier.pubmed 28429735
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.department SE/AOK/K/Onkológiai Központ
dc.contributor.institution Semmelweis Egyetem

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