Egyszerű nézet Castellano I Metovic J Balmativola D Annaratone L Rangel N Vissio E Arisio R Macri L Pecchioni C Sarotto I Montarolo F Muscara F Marchio C Cassoni P Kulka, Janina Sapino A 2017-10-09T09:19:36Z 2017-10-09T09:19:36Z 2017
dc.identifier.citation pagination=e0182073, pages: 11; journalVolume=12; journalIssueNumber=8; journalTitle=PLOS ONE;
dc.identifier.uri doi:10.1371/journal.pone.0182073
dc.description.abstract BACKGROUND: The role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant NDc on the surgical approach to the nipple-areola complex, and (ii) to verify the association between malignant NDc and nipple malignancy. METHODS: We retrospectively analyzed a case series of 139 patients with NDc who underwent breast surgery. The clinical and histological findings, types of surgery with emphasis on nipple-areola complex amputation, immunohistochemical phenotypes of the carcinomas and measurements of the tumor-nipple distance were recorded. Additionally, in patients who showed HER2-positive lesions on definitive surgery, we evaluated the HER2 immunocytochemistry of the NDc smears. RESULTS: Thirty-two malignant and 107 benign/borderline NDc diagnoses were identified. All 32 malignant-NDc cases were histologically confirmed as malignant. Thirty borderline/benign-NDc cases were histologically diagnosed as malignant (sensitivity 58%). The majority of the patients with malignant NDc were treated with nipple-areola complex amputations in both the mastectomy and conservative surgery groups (P<0.001, chi251.77). Nipple involvement was strongly associated with HER2-positive ductal carcinoma in-situ (P<0.001, chi211.98). HER2 immunocytochemistry on the NDc revealed a 100% correlation with the immunocytochemistry performed on the surgical tissues. CONCLUSIONS: Malignant NDc influenced surgical management. The association of malignant NDc with nipple involvement is highly related to ductal carcinoma in-situ with HER2 overexpression. In case of HER2 positive NDc, nipple-areola complex involvement is more likely than in HER2 negative cases.
dc.relation.ispartof urn:issn:1932-6203
dc.title The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients
dc.type Journal Article 2017-10-03T12:43:22Z
dc.language.rfc3066 en
dc.identifier.mtmt 3273993
dc.identifier.pubmed 28806416
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.institution Semmelweis Egyetem

Kapcsolódó fájlok:

A fájl jelenleg csak egyetemi IP címről érhető el.


Ez a rekord az alábbi gyűjteményekben szerepel:

Egyszerű nézet