dc.contributor.author |
Dulic S |
|
dc.contributor.author |
Vasarhelyi Z |
|
dc.contributor.author |
Sava, Florentina |
|
dc.contributor.author |
Berta, László Gergely |
|
dc.contributor.author |
Szalay, Balázs |
|
dc.contributor.author |
Toldi, Gergely |
|
dc.contributor.author |
Kovács, László |
|
dc.contributor.author |
Balog, Attila |
|
dc.date.accessioned |
2018-02-16T10:29:07Z |
|
dc.date.available |
2018-02-16T10:29:07Z |
|
dc.date.issued |
2017 |
|
dc.identifier.citation |
pagination=6894374, 19 pages;
journalVolume=2017;
journalTitle=MEDIATORS OF INFLAMMATION; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/4701 |
|
dc.identifier.uri |
doi:10.1155/2017/6894374 |
|
dc.description.abstract |
Data on the impact of biological therapies on the T-cell phenotype in rheumatoid arthritis are limited. Here, we prospectively measured the percentages of 15 circulating T-cell subtypes using flow cytometry. We obtained transversal and longitudinal data in 30 anti-TNF responders, 19 secondary anti-TNF nonresponders, and 43 IL-6R antagonist responders, before, 8 weeks and at least 6 months after biological therapy. Untreated RA patients and healthy controls were also included. The important findings are the following: ( 1) the proportion of regulatory T-cells (Tregs) which are decreased in untreated RA patients becomes normal in all long-term-treated groups; ( 2) in anti-TNF responders as well as in nonresponders, the frequencies of naive CD4+ and CD8+ cells are lower, whereas those of proinflammatory Th1, Th2, and Th17 cells and HLA-DR+-activated cells are higher than those in untreated RA or healthy controls; ( 3) in IL-6R responders, Th1 proportion is decreased, while that of Th2 and Th17 is increased as compared to that in anti-TNF-treated patients and controls; ( 4) pending confirmation, a CD4CD69 ratio <2.43 at baseline, could be useful to predict a good therapeutic response to anti-TNF therapy. This study provides comprehensive information regarding the long-term impacts of those biological therapies on the ecotaxis of T-cells in RA. |
|
dc.relation.ispartof |
urn:issn:0962-9351 |
|
dc.title |
T-Cell Subsets in Rheumatoid Arthritis Patients on Long-Term Anti-TNF or IL-6 Receptor Blocker Therapy |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-02-06T09:09:53Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3288491 |
|
dc.identifier.wos |
000413592400001 |
|
dc.identifier.pubmed |
29209104 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|