Kivonat:
Arterial stiffness increases with age. This process is
accelerated by
end-stage renal disease (ESRD). Pulse wave velocity (PWV)
increases
with arterial stiffness. In this study, PWV of 133 healthy
individuals
(6-23 y of age) and 11 patients on dialysis was measured to
establish
the normal values of PWV and to compare them with those in ESRD.
Age-matched (A-C) and height- and weight-matched (H/W-C) control
groups
were used. Thereafter, PWV was indexed to height and the data
were
reevaluated. The role of the risk factors including serum
calcium,
phosphate, parathyroid hormone (PTH), and the time on dialysis
was
analyzed using a score system. PWV correlated with age, weight,
height,
blood pressure, and heart rate. ESRD patients were smaller than
A-C and
older than HAV-C. PWV of patients with ESRD did not differ from
A-C;
however, it was elevated in comparison to HAV-C. In both healthy
and
ESRD patients, the PWV/height ratio was independent of age.
PWV/height
was increased in ESRD. There was a correlation between
PWV/height and
the risk factor score. Controls matched for height and weight or
PWV/height should be used in cases of growth failure. A number
of risk
factors responsible for increased arterial stiffness are present
in
ESRD.