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dc.contributor TéT:TÉTSIN-CELLTHER
dc.contributor TÁMOP:TÁMOP-4.2.1/B09/1/KMR-2010-0001
dc.contributor OTKA:83803
dc.contributor MTA Bolyai pályázat:
dc.contributor Öveges pályázat:
dc.contributor.author Vácz, Gabriella
dc.contributor.author Cselenyák, Attila
dc.contributor.author Cserép Zs
dc.contributor.author Benkő, Rita
dc.contributor.author Kovács E
dc.contributor.author Pankotai E
dc.contributor.author Lindenmair A
dc.contributor.author Wolbank S
dc.contributor.author Schwarz CM
dc.contributor.author Horváthy, Dénes
dc.contributor.author Kiss, Levente
dc.contributor.author Hornyák, István
dc.contributor.author Lacza, Zsombor
dc.date.accessioned 2018-09-19T08:59:25Z
dc.date.available 2018-09-19T08:59:25Z
dc.date.issued 2016
dc.identifier 85009135151
dc.identifier.citation pagination=164-171; journalVolume=8; journalIssueNumber=4; journalTitle=INTERVENTIONAL MEDICINE AND APPLIED SCIENCE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/4811
dc.identifier.uri doi:10.1556/1646.8.2016.4.6
dc.description.abstract Purpose: Human amniotic epithelial cells (hAECs) are promising tools for endothelial repair in vascular regenerative medicine. We hypothesized that these epithelial cells are capable of repairing the damaged endothelial layer following balloon injury of the carotid artery in adult male rats. Results: Two days after injury, the transplanted hAECs were observed at the luminal side of the arterial wall. Then, 4 weeks after the injury, significant intimal thickening was observed in both untreated and cell implanted vessels. Constriction was decreased in both implanted and control animals. Immunohistochemical analysis showed a few surviving cells in the intact arterial wall, but no cells were observed at the site of injury. Interestingly, acetylcholine-induced dilation was preserved in the intact side and the sham-transplanted injured arteries, but it was a trend toward decreased vasodilation in the hAECs' transplanted vessels. Conclusion: We conclude that hAECs were able to incorporate into the arterial wall without immunosuppression, but failed to improve vascular function, highlighting that morphological implantation does not necessarily result in functional benefits and underscoring the need to understand other mechanisms of endothelial regeneration. © 2016 The Author(s).
dc.relation.ispartof urn:issn:2061-1617
dc.title Effects of amniotic epithelial cell transplantation in endothelial injury
dc.type Journal Article
dc.date.updated 2018-02-16T12:29:03Z
dc.language.rfc3066 en
dc.identifier.mtmt 3162689
dc.identifier.wos 000390989800006
dc.identifier.pubmed 28180006
dc.contributor.department SE/KSZE/Klinikai Kísérleti Kutató Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote FELTÖLTŐ: Sonnevend Kinga - sonnevend.kinga@med.semmelweis-univ.hu


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