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dc.contributor.author Németh, Endre
dc.contributor.author Vig K
dc.contributor.author Rácz, Kristóf
dc.contributor.author Koritsanszky KB
dc.contributor.author Ronkay KI
dc.contributor.author Hamvas FP
dc.contributor.author Borbely C
dc.contributor.author Eőry, Ajándék
dc.contributor.author Merkely, Béla Péter
dc.contributor.author Gál, János
dc.date.accessioned 2018-02-22T13:19:40Z
dc.date.available 2018-02-22T13:19:40Z
dc.date.issued 2017
dc.identifier.citation pagination=113, 10 pages; journalVolume=17; journalIssueNumber=1; journalTitle=BMC ANESTHESIOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/4863
dc.identifier.uri doi:10.1186/s12871-017-0408-1
dc.description.abstract BACKGROUND: The role of non-infective inflammatory response (IR) in the aetiology of postoperative cognitive dysfunction (POCD) is still controversial. The aim of this controlled, prospective observational study was to assess the possible relationship between the grade of IR, defined by procalcitonin (PCT) changes, and development of POCD related to cardiac surgery. METHODS: Forty-two patients, who were >/= 60 years of age and scheduled for elective cardiac surgery, were separated into the low inflammatory (LIR) and high inflammatory (HIR) response groups based on their PCT levels measured on the first postoperative day. A matched normative control group of 32 subjects was recruited from primary care practice. The PCT and C-reactive protein (CRP) levels were monitored daily during the first five postoperative days. The cognitive function and mood state were preoperatively tested with a set of five neurocognitive tests and two mood inventories and at the seventh postoperative day. The Reliable Change Index modified for practice (RCIp) using data from normative controls was applied to determine the significant decline in test performance. RESULTS: The LIR (n = 20) and HIR (n = 22) groups differed significantly in the PCT (p < 0.001) but not in the CRP time courses. The incidence of POCD at the first postoperative week was 35.7% in the cohort. The LIR and HIR groups did not vary in the RCIp Z scores of neurocognitive tests and frequencies of POCD (7 vs 8 cases, respectively, p > 0.05). Additionally, there was no difference in the mood states, anxiety levels and perioperative parameters known to influence the development of POCD. CONCLUSIONS: In this study, the magnitude of the non-infective inflammatory response generated by on-pump cardiac surgery did not influence the development of POCD in the early postoperative period in elderly patients.
dc.relation.ispartof urn:issn:1471-2253
dc.title Influence of the postoperative inflammatory response on cognitive decline in elderly patients undergoing on-pump cardiac surgery: a controlled, prospective observational study
dc.type Journal Article
dc.date.updated 2018-02-19T14:34:29Z
dc.language.rfc3066 en
dc.identifier.mtmt 3264492
dc.identifier.pubmed 28851286
dc.contributor.department SE/AOK/K/Aneszteziológiai és Intenzív Terápiás Klinika
dc.contributor.department SE/AOK/K/Családorvosi Tanszék
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék [2017.10.31]
dc.contributor.institution Semmelweis Egyetem


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