Show simple item record Butykai, Ádám Orbánová, Agnesa Kocsis, Vilmos Szaller, Dávid Bordács, Sándor Tátrainé Szekeres, Erzsébet Kiss, László Bóta, Attila Vértessy, Beáta (Grolmuszné) Zelles, Tivadar Kézsmárki, István 2018-06-11T07:48:49Z 2018-06-11T07:48:49Z 2013
dc.identifier 84875204535
dc.identifier.citation pagination=1431, pages: 10; journalVolume=3; journalTitle=SCIENTIFIC REPORTS;
dc.identifier.uri doi:10.1038/srep01431
dc.description.abstract The need to develop new methods for the high-sensitivity diagnosis of malaria has initiated a global activity in medical and interdisciplinary sciences. Most of the diverse variety of emerging techniques are based on research-grade instruments, sophisticated reagent-based assays or rely on expertise. Here, we suggest an alternative optical methodology with an easy-to- use and cost-effective instrumentation based on unique properties of malaria pigment reported previously and determined quantitatively in the present study. Malaria pigment, also called hemozoin, is an insoluble microcrystalline form of heme. These crystallites show remarkable magnetic and optical anisotropy distinctly from any other components of blood. As a consequence, they can simultaneously act as magnetically driven micro-rotors and spinning polarizers in suspensions. These properties can gain importance not only in malaria diagnosis and therapies, where hemozoin is considered as drug target or immune modulator, but also in the magnetic manipulation of cells and tissues on the microscopic scale.
dc.relation.ispartof urn:issn:2045-2322
dc.title Malaria pigment crystals as magnetic micro-rotors: Key for high-sensitivity diagnosis
dc.type Journal Article 2018-02-20T13:22:32Z
dc.language.rfc3066 en
dc.identifier.mtmt 2242098
dc.identifier.wos 000315939200002
dc.identifier.pubmed 23478535
dc.contributor.department MTA TTK/Molekuláris Farmakológiai Intézet [2013.12.31]
dc.contributor.department MTA Wigner FK/Szilárdtestfizikai és Optikai Intézet
dc.contributor.department MTA TTK/AKI/AKI jogelőd 2014 előtt [2014.12.31]
dc.contributor.department BME/TTK/FI/FT/MTA-BME Kondenzált Anyagok Fizikája Kutatócsoport
dc.contributor.department BME/TTK/FI/Fizika Tanszék
dc.contributor.department BME/VBK/Alkalmazott Biotechnológia és Élelmiszertudományi Tanszék
dc.contributor.department SE/FOK/Orálbiológiai Tanszék
dc.contributor.institution MTA Természettudományi Kutatóközpont
dc.contributor.institution MTA Wigner Fizikai Kutatóközpont
dc.contributor.institution Budapesti Műszaki és Gazdaságtudományi Egyetem
dc.contributor.institution Semmelweis Egyetem

Files in this item

This file is available only from Semmelweis network


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account