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dc.contributor.author Bertóti Regina
dc.contributor.author Vasas Gábor
dc.contributor.author Gonda Sándor
dc.contributor.author Nguyen Minh Nhat
dc.contributor.author Szőke Éva
dc.contributor.author Jakab Ágnes
dc.contributor.author Pócsi István
dc.contributor.author Emri Tamás
dc.date.accessioned 2018-03-03T11:43:57Z
dc.date.available 2018-03-03T11:43:57Z
dc.date.issued 2016
dc.identifier 84978285796
dc.identifier.citation pagination=1071-1079; journalVolume=56; journalIssueNumber=10; journalTitle=JOURNAL OF BASIC MICROBIOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5044
dc.identifier.uri doi:10.1002/jobm.201600082
dc.description.abstract Horseradish essential oil (HREO; a natural mixture of different isothiocyanates) had strong fungicide effect against Candida albicans both in volatile and liquid phase. In liquid phase this antifungal effect was more significant than those of its main components allyl, and 2-phenylethyl isothiocyanate. HREO, at sublethal concentration, induced oxidative stress which was characterized with elevated superoxide content and up-regulated specific glutathione reductase, glutathione peroxidase, catalase and superoxide dismutase activities. Induction of specific glutathione S-transferase activities as marker of glutathione (GSH) dependent detoxification was also observed. At higher concentration, HREO depleted the GSH pool, increased heavily the superoxide production and killed the cells rapidly. HREO and the GSH pool depleting agent, 1-chlore-2,4-dinitrobenzene showed strong synergism when they were applied together to kill C. albicans cells. Based on all these, we assume that GSH metabolism protects fungi against isothiocyanates. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.relation.ispartof urn:issn:0233-111X
dc.title Glutathione protects Candida albicans against horseradish volatile oil
dc.type Journal Article
dc.date.updated 2018-02-28T14:02:31Z
dc.language.rfc3066 en
dc.identifier.mtmt 3109416
dc.identifier.wos 000385657900003
dc.contributor.department SE/GYTK/Farmakognózia Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote FELTÖLTŐ: Reményi Zsuzsa - titkarsag@drog.sote.hu


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