dc.contributor.author |
Hetthéssy Judit |
|
dc.contributor.author |
Tőkés Anna-Mária |
|
dc.contributor.author |
Kérész S |
|
dc.contributor.author |
Balla Petra |
|
dc.contributor.author |
Dörnyei Gabriella |
|
dc.contributor.author |
Monos Emil |
|
dc.contributor.author |
Nádasy György László |
|
dc.date.accessioned |
2018-03-03T13:13:26Z |
|
dc.date.available |
2018-03-03T13:13:26Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
pagination=128-137;
journalVolume=33;
journalIssueNumber=2;
journalTitle=PHLEBOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5048 |
|
dc.identifier.uri |
doi:10.1177/0268355516688984 |
|
dc.description.abstract |
Objective To better understand factors that may play a role in the development of varicosities. Methods We induced combined flow-pressure disturbance in the saphenous system of the rat by performing chronic partial clipping of the main branch. Biomechanical and quantitative histological testing was undertaken. Results A rich microvenous network developed. Bloodflow decreased to 0.65 +/- 0.18 microl/s (control side, 3.5 +/- 1.4 microl/s) and pressure elevated to 6.8 +/- 0.7 mmHg (control side, 2.3 +/- 0.2 mmHg, p < 0.05). Involution of the wall and lumen was observed (16.5%, 28.7% and 35.5% reduction in outer diameter, wall thickness and wall mass respectively, p < 0.05). Elevated macrophage (CD68) and cell division (Ki67) activity was observed. Elastic tissue and smooth muscle actin became less concentrated in the inner medial layers. Conclusions Low-flow induced morphological shrinking of the lumen in veins may override pressure-induced morphological distension. Loosening of the force-bearing elements during flow-induced wall remodeling may be an important pathological component in varicosity. |
|
dc.relation.ispartof |
urn:issn:0268-3555 |
|
dc.title |
High pressure-low flow remodeling of the rat saphenous vein wall |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-02-28T14:31:40Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3170325 |
|
dc.identifier.pubmed |
28094663 |
|
dc.contributor.department |
SE/AOK/K/Ortopédiai Klinika |
|
dc.contributor.department |
SE/AOK/I/IISZPI/MTA-SE Molekuláris Onkológia Kutatócsoport |
|
dc.contributor.department |
SE/ETK2007/AEI/Morfológiai és Fiziológiai Tanszék |
|
dc.contributor.department |
SE/KSZE/Klinikai Kísérleti Kutató Intézet |
|
dc.contributor.department |
SE/AOK/I/Élettani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|