Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice

dc.contributor.author	Vereczki Viktória
dc.contributor.author	Mansour Josef
dc.contributor.author	Pour-Ghaz Issa
dc.contributor.author	Bodnár Ibolya
dc.contributor.author	Pintér Ottó
dc.contributor.author	Zelena Dóra
dc.contributor.author	Oszwald Erzsébet
dc.contributor.author	Ádám-Vizi Veronika
dc.contributor.author	Chinopoulos Christos
dc.date.accessioned	2018-10-12T09:38:08Z
dc.date.available	2018-10-12T09:38:08Z
dc.date.issued	2017
dc.identifier	85015058708
dc.identifier.citation	pagination=115-126; journalVolume=34; journalTitle=MITOCHONDRION;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/5091
dc.identifier.uri	doi:10.1016/j.mito.2017.03.003
dc.description.abstract	Abstract Cyclophilin D (cypD) modulates the properties of the permeability transition pore, a phenomenon implicated in the manifestation of many diseases including aging. Here, we examined the effects of partial or complete deletion of cypD on i) lifespan, ii) forebrain protein expression of 18 aging markers as well as regional expression of GFAP, mGluR1, and alpha-synuclein, and iii) behaviour of aged (> 24 month) male and female mice. Both male and female cypD heterozygous but not KO mice exhibited increased lifespans compared to WT littermates, associated with alterations in the protein expression of some markers, albeit without exhibiting changes in behaviour.
dc.relation.ispartof	urn:issn:1567-7249
dc.title	Cyclophilin D regulates lifespan and protein expression of aging markers in the brain of mice
dc.type	Journal Article
dc.date.updated	2018-03-09T10:11:05Z
dc.language.rfc3066	en
dc.identifier.mtmt	3204332
dc.contributor.department	SE/AOK/I/OBI/MTA-SE Neurobiokémiai Kutatócsoport
dc.contributor.department	SE/AOK/I/Anatómiai, Szövet- és Fejlődéstani Intézet