A laktátdehidrogenáz (LDH)  prognosztikai jelentősége  az onkológiában

dc.contributor.author	Deme D
dc.contributor.author	Telekes, András
dc.date.accessioned	2018-04-27T08:55:13Z
dc.date.available	2018-04-27T08:55:13Z
dc.date.issued	2017
dc.identifier	85039704562
dc.identifier.citation	pagination=1977-1988; journalVolume=158; journalIssueNumber=50; journalTitle=ORVOSI HETILAP;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/5119
dc.identifier.uri	doi:10.1556/650.2017.30890
dc.description.abstract	Glycolysis is increased in most of the malignant cells, providing the largest proportion of energy needed for cell proliferation. Lactate dehydrogenase (LDH) catalyses the reversible process of pyruvate to lactate in anaerobic condition. LDHA isoenzyme expressed mainly by malignant cells, significantly increases lactate formation. Lactate induces the proliferation of oxygenated malignant cells, angiogenesis, and inhibits the innate and adaptive immune responses. Baseline serum LDH elevation correlates with shorter survival. The authors review the relevant studies exploring the correlation between LDH elevation and the prognosis of malignant diseases. Orv Hetil. 2017; 158(50): 1977-1988.
dc.relation.ispartof	urn:issn:0030-6002
dc.title	A laktátdehidrogenáz (LDH) prognosztikai jelentősége az onkológiában
dc.type	Journal Article
dc.date.updated	2018-03-12T14:04:54Z
dc.language.rfc3066	hu
dc.identifier.mtmt	3309457
dc.identifier.pubmed	29226713
dc.contributor.department	SE/AOK/K/IISZBK/II. Sz. Belgyógyászati Klinika Geriátriai Tanszéki Csoport
dc.contributor.institution	Semmelweis Egyetem