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dc.contributor.author Virág, József
dc.contributor.author Haberler C
dc.contributor.author Baksa, Gábor
dc.contributor.author Piurkó V
dc.contributor.author Hegedűs, Zita
dc.contributor.author Reiniger, Lilla
dc.contributor.author Bálint, Katalin
dc.contributor.author Chocholous M
dc.contributor.author Kiss, András
dc.contributor.author Lotz, Gábor
dc.contributor.author Glasz, Tibor
dc.contributor.author Schaff, Zsuzsa
dc.contributor.author Garami, Miklós
dc.contributor.author Hegedűs, Balázs
dc.date.accessioned 2018-07-19T06:29:24Z
dc.date.available 2018-07-19T06:29:24Z
dc.date.issued 2017
dc.identifier 84978086943
dc.identifier.citation pagination=245-252; journalVolume=23; journalIssueNumber=2; journalTitle=PATHOLOGY AND ONCOLOGY RESEARCH;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5120
dc.identifier.uri doi:10.1007/s12253-016-0084-3
dc.description.abstract Ependymomas are common pediatric brain tumors that originate from the ependyma and characterized by poor prognosis due to frequent recurrence. However, the current WHO grading system fails to accurately predict outcome. In a retrospective study, we analyzed 54 intracranial pediatric ependymomas and found a significantly higher overall survival in supratentorial cases when compared to infratentorial tumors. Next we performed region-specific immunohistochemical analysis of the ependyma in neonatal and adult ependyma from the central canal of spinal cord to the choroid plexus of lateral ventricles for components of cell-cell junctions including cadherins, claudins and occludin. We found robust claudin-5 expression in the choroid plexus epithelia but not in other compartments of the ependyma. Ultrastructural studies demonstrated distinct regional differences in cell-cell junction organization. Surprisingly, we found that 9 out of 20 supratentorial but not infratentorial ependymomas expressed high levels of the brain endothelial tight junction component claudin-5 in tumor cells. Importantly, we observed an increased overall survival in claudin-5 expressing supratentorial ependymoma. Our data indicates that claudin-5 expressing ependymomas may follow a distinct course of disease. The assessment of claudin-5 expression in ependymoma has the potential to become a useful prognostic marker in this pediatric malignancy.
dc.relation.ispartof urn:issn:1219-4956
dc.title Region specific differences of claudin-5 expression in pediatric intracranial ependymomas: Potential prognostic role in supratentorial cases
dc.type Journal Article
dc.date.updated 2018-03-12T14:08:19Z
dc.language.rfc3066 en
dc.identifier.mtmt 3090563
dc.identifier.wos 000399000200003
dc.identifier.pubmed 27395057
dc.contributor.department SE/AOK/I/IISZPI/MTA-SE Molekuláris Onkológia Kutatócsoport
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.department SE/AOK/I/Anatómiai, Szövet- és Fejlődéstani Intézet
dc.contributor.department SE/AOK/I/II. Sz. Patológiai Intézet
dc.contributor.department SE/AOK/I/IISZPI/MTA-SE-NAP B Agymetasztázis Kutatócsoport
dc.contributor.department SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote BH and MG are sharing the senior authorship.


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