dc.contributor.author |
Kirilly Eszter |
|
dc.contributor.author |
Molnár Eszter |
|
dc.contributor.author |
Balogh B |
|
dc.contributor.author |
Kántor Sándor |
|
dc.contributor.author |
Hansson SR |
|
dc.contributor.author |
Palkovits Miklós |
|
dc.contributor.author |
Bagdy György |
|
dc.date.accessioned |
2018-03-21T20:41:52Z |
|
dc.date.available |
2018-03-21T20:41:52Z |
|
dc.date.issued |
2008 |
|
dc.identifier |
50849127886 |
|
dc.identifier.citation |
pagination=795-809;
journalVolume=11;
journalIssueNumber=6;
journalTitle=INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5182 |
|
dc.identifier.uri |
doi:10.1017/S1461145708008535 |
|
dc.description.abstract |
The recreational drug ecstasy [3,4-methylenedioxymethamphetamine
(MDMA)], has been found to selectively damage brain serotonin neurons
in experimental animals, and probably in human MDMA users, but detailed
morphometric analyses and parallel functional measures during damage
and recovery are missing. Since there is evidence that serotonin
regulates sleep, we have compared serotonergic markers parallel with
detailed analysis of sleep patterns at three time-points within 180 d
after a single dose of 15 mg/kg MDMA in male Dark Agouti rats. At 7 d
and 21 d after MDMA treatment, significant (30-40%), widespread
reductions in serotonin transporter (5-HTT) density were detected in
the cerebral cortex, hippocampus, most parts of the hypothalamus, and
some of the brainstem nuclei. With the exception of the hippocampus,
general recovery was observed in the brain 180 d after treatment.
Transient increases followed by decreases were detected in 5-HTT mRNA
expression of dorsal and median raphe nuclei at 7 d and 21 d after the
treatment. Significant reductions in rapid eye movement (REM) sleep
latency, increases in delta power spectra in non-rapid eye movement
sleep and increased fragmentation of sleep were also detected, but all
these alterations disappeared by the 180th day. The present data
provide evidence for long-term, albeit, except for the hippocampus,
transient changes in the terminal and cellular regions of the
serotonergic system after this drug. Reduced REM latency and increased
sleep fragmentation are the most characteristic alterations of sleep
consistently described in depression using EEG sleep polygraphy. |
|
dc.relation.ispartof |
urn:issn:1461-1457 |
|
dc.title |
Decrease in REM latency and changes in sleep quality parallel serotonergic damage and recovery after MDMA: a longitudinal study over 180 days |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-03-19T08:34:56Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1130040 |
|
dc.identifier.wos |
000259706800005 |
|
dc.identifier.pubmed |
18261250 |
|
dc.contributor.department |
SE/AOK/I/Anatómiai, Szövet- és Fejlődéstani Intézet [2015.12.31] |
|
dc.contributor.department |
SE/AOK/I/Farmakológiai és Farmakoterápiás Intézet |
|
dc.contributor.department |
SE/GYTK/GYHATAS/MTA-SE Neuropszichofarmakológiai és Neurokémiai Kutatócsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|