Show simple item record Feijen EAM Font-Gonzalez A Van Dalen EC Van Der Pal HJH Reulen RC Winter DL Kuehni CE Haupt R Alessi D Byrne J Bárdi, Edit Jakab, Zsuzsanna Grabo D Garwicz S Jankovic M Levitt GA Skinner R Zaletel LZ Hjorth L Tissing WJE De Vathaire F Hawkins MM Kremer LCM 2018-06-11T07:29:30Z 2018-06-11T07:29:30Z 2016
dc.identifier 84992347151
dc.identifier.citation pagination=e0162778, pages: 11; journalVolume=11; journalIssueNumber=9; journalTitle=PLOS ONE;
dc.identifier.uri doi:10.1371/journal.pone.0162778
dc.description.abstract Background and Aim Childhood cancer survivors are at high risk of long-Termadverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. Methods Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data onsymptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected. Results The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient-And general practitioner-based questionnaires. Conclusion The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platformfor future research studies in childhood cancer patients. © 2016 Feijen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.relation.ispartof urn:issn:1932-6203
dc.title Late cardiac events after childhood cancer: Methodological aspects of the pan-european study pancaresurfup
dc.type Journal Article 2018-03-27T13:07:39Z
dc.language.rfc3066 en
dc.identifier.mtmt 3227331
dc.identifier.wos 000383891900017
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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