dc.contributor.author |
Celeng, Csilla |
|
dc.contributor.author |
de Keizer B |
|
dc.contributor.author |
Merkely, Béla Péter |
|
dc.contributor.author |
de Jong P |
|
dc.contributor.author |
Leiner T |
|
dc.contributor.author |
Takx RAP |
|
dc.date.accessioned |
2018-06-15T07:52:49Z |
|
dc.date.available |
2018-06-15T07:52:49Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
pagination=11; 10 pages;
journalVolume=20;
journalIssueNumber=2;
journalTitle=CURRENT CARDIOLOGY REPORTS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5351 |
|
dc.identifier.uri |
doi:10.1007/s11886-018-0953-3 |
|
dc.description.abstract |
PURPOSE OF REVIEW: With this review, we aim to summarize the role of positron emission tomography (PET) and near-infrared fluorescence imaging (NIRF) in the detection of atherosclerosis. RECENT FINDINGS: (18)F-FDG is an established measure of increased macrophage activity. However, due to its low specificity, new radiotracers have emerged for more specific detection of vascular inflammation and other high-risk plaque features such as microcalcification and neovascularization. Novel NIRF probes are engineered to sense endothelial damage as an early sign of plaque erosion as well as oxidized low-density lipoprotein (oxLDL) as a prime target for atherosclerosis. Integrated NIRF/OCT (optical coherence tomography) catheters enable to detect stent-associated microthrombi. Novel radiotracers can improve specificity of PET for imaging atherosclerosis. Advanced NIRF probes show promise for future application in human. Intravascular NIRF might play a prominent role in the detection of stent-induced vascular injury. |
|
dc.relation.ispartof |
urn:issn:1523-3782 |
|
dc.title |
PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-05-05T23:23:32Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3336767 |
|
dc.identifier.pubmed |
29435774 |
|
dc.contributor.department |
SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék |
|
dc.contributor.institution |
Semmelweis Egyetem |
|