dc.contributor.author |
Donnelly PM |
|
dc.contributor.author |
Kolossváry, Márton József |
|
dc.contributor.author |
Karády, Júlia |
|
dc.contributor.author |
Ball PA |
|
dc.contributor.author |
Kelly S |
|
dc.contributor.author |
Fitzsimons D |
|
dc.contributor.author |
Spence MS; |
|
dc.contributor.author |
Celeng, Csilla |
|
dc.contributor.author |
Horváth, Tamás |
|
dc.contributor.author |
Szilveszter, Bálint |
|
dc.contributor.author |
van Es HW |
|
dc.contributor.author |
Swaans MJ |
|
dc.contributor.author |
Merkely, Béla Péter |
|
dc.contributor.author |
Maurovich-Horvat, Pál |
|
dc.date.accessioned |
2018-06-15T08:22:16Z |
|
dc.date.available |
2018-06-15T08:22:16Z |
|
dc.date.issued |
2018 |
|
dc.identifier |
85032960063 |
|
dc.identifier.citation |
pagination=9-13;
journalVolume=121;
journalIssueNumber=1;
journalTitle=AMERICAN JOURNAL OF CARDIOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5354 |
|
dc.identifier.uri |
doi:10.1016/j.amjcard.2017.09.018 |
|
dc.description.abstract |
Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) is a new technique for the diagnosis of ischemic coronary artery stenoses. The aim of this prospective study was to evaluate the diagnostic performance of a novel on-site computed tomography-based fractional flow reserve algorithm (CT-FFR) compared with invasive FFR as the gold standard, and to determine whether its diagnostic performance is affected by interobserver variations in lumen segmentation. We enrolled 44 consecutive patients (64.6 +/- 8.9 years, 34% female) with 60 coronary atherosclerotic lesions who underwent coronary CTA and invasive coronary angiography in 2 centers. An FFR value </=0.8 was considered significant. Coronary CTA scans were evaluated by 2 expert readers, who manually adjusted the semiautomated coronary lumen segmentations for effective diameter stenosis (EDS) assessment and on-site CT-FFR simulation. The mean CT-FFR value was 0.77 +/- 0.15, whereas the mean EDS was 43.6 +/- 16.9%. The sensitivity, specificity, positive predictive value, and negative predictive value of CT-FFR versus EDS with a cutoff of 50% were the following: 91%, 72%, 63%, and 93% versus 52%, 87%, 69%, and 77%, respectively. The on-site CT-FFR demonstrated significantly better diagnostic performance compared with EDS (area under the curve 0.89 vs 0.74, respectively, p <0.001). The CT-FFR areas under the curve of the 2 readers did not show any significant difference (0.89 vs 0.88, p = 0.74). In conclusion, on-site CT-FFR simulation is feasible and has better diagnostic performance than anatomic stenosis assessment. Furthermore, the diagnostic performance of the on-site CT-FFR simulation algorithm does not depend on the readers' semiautomated lumen segmentation adjustments. |
|
dc.relation.ispartof |
urn:issn:0002-9149 |
|
dc.title |
Experience With an On-Site Coronary Computed Tomography-Derived Fractional Flow Reserve Algorithm for the Assessment of Intermediate Coronary Stenoses. |
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dc.type |
Journal Article |
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dc.date.updated |
2018-05-05T23:31:26Z |
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dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3287463 |
|
dc.identifier.wos |
WOS:000422614900002 |
|
dc.identifier.pubmed |
29103607 |
|
dc.contributor.department |
SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék |
|
dc.contributor.department |
SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/KARDI KZP_KARDIO-T/MTA-SE Lendület Kardiovaszkuláris Képalkotó Kutatócsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Merkely B and Maurovich-Horvat P contributed equally to this manuscript. |
|