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dc.contributor.author Donnelly PM
dc.contributor.author Kolossváry, Márton József
dc.contributor.author Karády, Júlia
dc.contributor.author Ball PA
dc.contributor.author Kelly S
dc.contributor.author Fitzsimons D
dc.contributor.author Spence MS;
dc.contributor.author Celeng, Csilla
dc.contributor.author Horváth, Tamás
dc.contributor.author Szilveszter, Bálint
dc.contributor.author van Es HW
dc.contributor.author Swaans MJ
dc.contributor.author Merkely, Béla Péter
dc.contributor.author Maurovich-Horvat, Pál
dc.date.accessioned 2018-06-15T08:22:16Z
dc.date.available 2018-06-15T08:22:16Z
dc.date.issued 2018
dc.identifier 85032960063
dc.identifier.citation pagination=9-13; journalVolume=121; journalIssueNumber=1; journalTitle=AMERICAN JOURNAL OF CARDIOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5354
dc.identifier.uri doi:10.1016/j.amjcard.2017.09.018
dc.description.abstract Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) is a new technique for the diagnosis of ischemic coronary artery stenoses. The aim of this prospective study was to evaluate the diagnostic performance of a novel on-site computed tomography-based fractional flow reserve algorithm (CT-FFR) compared with invasive FFR as the gold standard, and to determine whether its diagnostic performance is affected by interobserver variations in lumen segmentation. We enrolled 44 consecutive patients (64.6 +/- 8.9 years, 34% female) with 60 coronary atherosclerotic lesions who underwent coronary CTA and invasive coronary angiography in 2 centers. An FFR value </=0.8 was considered significant. Coronary CTA scans were evaluated by 2 expert readers, who manually adjusted the semiautomated coronary lumen segmentations for effective diameter stenosis (EDS) assessment and on-site CT-FFR simulation. The mean CT-FFR value was 0.77 +/- 0.15, whereas the mean EDS was 43.6 +/- 16.9%. The sensitivity, specificity, positive predictive value, and negative predictive value of CT-FFR versus EDS with a cutoff of 50% were the following: 91%, 72%, 63%, and 93% versus 52%, 87%, 69%, and 77%, respectively. The on-site CT-FFR demonstrated significantly better diagnostic performance compared with EDS (area under the curve 0.89 vs 0.74, respectively, p <0.001). The CT-FFR areas under the curve of the 2 readers did not show any significant difference (0.89 vs 0.88, p = 0.74). In conclusion, on-site CT-FFR simulation is feasible and has better diagnostic performance than anatomic stenosis assessment. Furthermore, the diagnostic performance of the on-site CT-FFR simulation algorithm does not depend on the readers' semiautomated lumen segmentation adjustments.
dc.relation.ispartof urn:issn:0002-9149
dc.title Experience With an On-Site Coronary Computed Tomography-Derived Fractional Flow Reserve Algorithm for the Assessment of Intermediate Coronary Stenoses.
dc.type Journal Article
dc.date.updated 2018-05-05T23:31:26Z
dc.language.rfc3066 en
dc.identifier.mtmt 3287463
dc.identifier.wos WOS:000422614900002
dc.identifier.pubmed 29103607
dc.contributor.department SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/KARDI KZP_KARDIO-T/MTA-SE Lendület Kardiovaszkuláris Képalkotó Kutatócsoport
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Merkely B and Maurovich-Horvat P contributed equally to this manuscript.


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