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dc.contributor.author Jermendy, Ádám Levente
dc.contributor.author Kolossváry, Márton József
dc.contributor.author Drobni, Zsófia
dc.contributor.author Tárnoki, Ádám Domonkos
dc.contributor.author Tárnoki, Dávid László
dc.contributor.author Karády, Júlia
dc.contributor.author Voros S
dc.contributor.author Lamb HJ
dc.contributor.author Merkely, Béla Péter
dc.contributor.author Jermendy G
dc.contributor.author Maurovich-Horvat, Pál
dc.date.accessioned 2018-06-15T08:26:01Z
dc.date.available 2018-06-15T08:26:01Z
dc.date.issued 2018
dc.identifier 85041675011
dc.identifier.citation pagination=163-168; journalVolume=42; journalTitle=INTERNATIONAL JOURNAL OF OBESITY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5355
dc.identifier.uri doi:10.1038/ijo.2017.212
dc.description.abstract BACKGROUND/OBJECTIVE: Various adipose tissue compartments play an important role in the development of cardiometabolic diseases. The quantity of different fat compartments is influenced by genetic and environmental factors. The aim of our study was to evaluate the magnitude of genetic and environmental effects on epicardial, subcutaneous and visceral adipose tissue (EAT, SAT and VAT) quantities in a cohort of adult twin pairs. SUBJECTS/METHODS: In this cross-sectional study we investigated adult twins (57 monozygotic [MZ] and 33 dizygotic [DZ] same-gender twin pairs; 180 twin subjects). We measured EAT volume using ECG-gated native CT scan of the heart, and abdominal SAT and VAT areas were quantified between the third and fourth lumbar vertebra on native CT images. We calculated genetic and environmental impact on the size of various adipose tissue compartments by analyzing co-twin correlations in MZ and DZ pairs separately, furthermore by using genetic structural equation models. RESULTS: In co-twin analysis, MZ twins had stronger correlations than DZ twins for EAT (rMZ=0.81, rDZ=0.32), similarly to SAT and VAT quantities (rMZ=0.80, rDZ=0.68 and rMZ=0.79, rDZ=0.48, respectively). In multi-trait model fitting analysis, the overall contribution of genetic factors to EAT, SAT and VAT volumes were 80, 78 and 70% whereas environmental factors were 20, 22 and 30%, respectively. Common pathway model analyses indicated that none of the EAT, SAT and VAT phenotypes was independent of the other two. CONCLUSIONS: Genetic factors have substantial influence, while environmental factors have only a modest impact on EAT volume, abdominal SAT and VAT quantities. There is a considerable amount of common genetic background influencing the quantities of all three adipose tissue compartments.International Journal of Obesity accepted article preview online, 30 August 2017. doi:10.1038/ijo.2017.212.
dc.relation.ispartof urn:issn:0307-0565
dc.title Assessing genetic and environmental influences on epicardial and abdominal adipose tissue quantities: A classical twin study.
dc.type Journal Article
dc.date.updated 2018-05-05T23:33:25Z
dc.language.rfc3066 en
dc.identifier.mtmt 3263057
dc.identifier.wos 000424505200006
dc.identifier.pubmed 28852208
dc.contributor.department SE/AOK/K/Radiológiai és Onkoterápiás Klinika
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék
dc.contributor.department SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/KARDI KZP_KARDIO-T/MTA-SE Lendület Kardiovaszkuláris Képalkotó Kutatócsoport
dc.contributor.institution Semmelweis Egyetem


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