dc.contributor.author |
Németh, Endre |
|
dc.contributor.author |
Kovács, Enikő |
|
dc.contributor.author |
Rácz, Kristóf |
|
dc.contributor.author |
Soltesz A |
|
dc.contributor.author |
Szigeti S |
|
dc.contributor.author |
Kiss N |
|
dc.contributor.author |
Csikos G |
|
dc.contributor.author |
Koritsanszky KB |
|
dc.contributor.author |
Berzsenyi V |
|
dc.contributor.author |
Trembickij G |
|
dc.contributor.author |
Fabry S |
|
dc.contributor.author |
Prohászka, Zoltán |
|
dc.contributor.author |
Merkely, Béla Péter |
|
dc.contributor.author |
Gál, János |
|
dc.date.accessioned |
2018-06-19T08:48:55Z |
|
dc.date.available |
2018-06-19T08:48:55Z |
|
dc.date.issued |
2018 |
|
dc.identifier.citation |
pagination=e13211, 11 pages;
journalVolume=32;
journalIssueNumber=4;
journalTitle=CLINICAL TRANSPLANTATION; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5367 |
|
dc.identifier.uri |
doi:10.1111/ctr.13211 |
|
dc.description.abstract |
AIM: The aim of this study was to assess the influence of intraoperative cytokine adsorption on the perioperative vasoplegia, inflammatory response and outcome during orthotopic heart transplantation (OHT). METHODS: 84 OHT patients were separated into the cytokine adsorption (CA) treated group or controls. Vasopressor demand, inflammatory response described by procalcitonin and C-reactive protein and postoperative outcome were assessed performing propensity score matching. RESULTS: In the 16 matched pairs, the median noradrenaline requirement was significantly less in the CA-treated patients than in the controls on the first and second postoperative days (0.14 vs 0.3mug*kg(-1) *min(-1) , P=0.039 and 0.06 vs 0.32mug*kg(-1) *min(-1) , P=0.047). The inflammatory responses were similar in the two groups. There was a trend towards shorter length of mechanical ventilation and intensive care unit (ICU) stay in the CA-treated group compared to the controls. No difference in adverse events was observed between the two groups. However, the frequency of renal replacement therapy was significantly less in the CA-treated than in controls (P=0.031). CONCLUSIONS: Intraoperative CA treatment was associated with reduced vasopressor demand and less frequent renal replacement therapy with a favorable tendency in length of mechanical ventilation and ICU stay. CA treatment was not linked to higher rates of adverse events. This article is protected by copyright. All rights reserved. |
|
dc.relation.ispartof |
urn:issn:0902-0063 |
|
dc.title |
Impact of intraoperative cytokine adsorption on outcome of patients undergoing orthotopic heart transplantation - an observational study |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-05-06T00:19:41Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3332633 |
|
dc.identifier.pubmed |
29377282 |
|
dc.contributor.department |
SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Aneszteziológiai és Intenzív Terápiás Klinika |
|
dc.contributor.department |
SE/AOK/K/III. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|