Synthesis and configurational assignment of 1,2-dihydroimidazo[5,1-b]quinazoline-3,9-diones: novel NMDA receptor antagonists

dc.contributor.author	Váradi András
dc.contributor.author	Horváth Péter
dc.contributor.author	Kurtán Tibor
dc.contributor.author	Mándi Attila
dc.contributor.author	Tóth Gergő
dc.contributor.author	Gergely András
dc.contributor.author	Kökösi József
dc.date.accessioned	2018-05-10T16:34:32Z
dc.date.available	2018-05-10T16:34:32Z
dc.date.issued	2012
dc.identifier	84869088753
dc.identifier.citation	pagination=10365-10371; journalVolume=68; journalIssueNumber=50; journalTitle=TETRAHEDRON;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/5379
dc.identifier.uri	doi:10.1016/j.tet.2012.09.086
dc.description.abstract	NMDA receptors form a major subdivision of the ionotropic glutamate receptor family that mediates excitatory synaptic transmission in the brain. Series of 1-substituted 1,2-dihydroimidazo[5,1-b]quinazolinediones were synthesized and found to have potent nanomolar activity at the glycine site of the NMDA receptor. Imidazoquinazolinediones were prepared by cyclocondensation of 4-oxo-quinazoline-2-carboxamide with aldehydes and orthoesters with good yields. The formed enantiomers were separated by chiral HPLC. The absolute configuration of pure enantiomers is elucidated by combined CD/Quantumchemical time-dependent DFT calculation method (TDDFT). © 2012 Elsevier Ltd. All rights reserved.
dc.relation.ispartof	urn:issn:0040-4020
dc.title	Synthesis and configurational assignment of 1,2-dihydroimidazo[5,1-b]quinazoline-3,9-diones: novel NMDA receptor antagonists
dc.type	Journal Article
dc.date.updated	2018-05-09T15:24:49Z
dc.language.rfc3066	en
dc.identifier.mtmt	2111166
dc.identifier.wos	000311135700014
dc.identifier.scopus	84869088753
dc.contributor.department	SE/GYTK/Gyógyszerészi Kémiai Intézet
dc.contributor.institution	Semmelweis Egyetem