dc.contributor.author |
Jankovics Péter, |
|
dc.contributor.author |
Lohner Szilvia, |
|
dc.contributor.author |
Darcsi, András |
|
dc.contributor.author |
Németh-Palotás Júlia, |
|
dc.contributor.author |
Béni, Szabolcs |
|
dc.date.accessioned |
2014-11-16T18:03:23Z |
|
dc.date.available |
2014-11-16T18:03:23Z |
|
dc.date.issued |
2013 |
|
dc.identifier |
84871897475 |
|
dc.identifier.citation |
pagination=83-91;
journalVolume=74;
journalTitle=JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/541 |
|
dc.identifier.uri |
doi:10.1016/j.jpba.2012.10.013 |
|
dc.description.abstract |
A new derivative of vardenafil was detected in an alleged herbal dietary supplement and identified as 2-(2-ethoxy-5-(4-(2-hydroxyethyl)piperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propyl-imidazo[1,5-f][1,2,4]triazin-4(3H)-thione. Structure elucidation was carried out by LC–UV–MS/MS and NMR. Results obtained with high resolution MS and IR spectroscopy confirmed the proposed chemical structure. The compound was distinguished from hydroxyvardenafil, a second active substance identified in the same product, by the conversion of the oxo group to a thio group on the imidazo-triazin moiety. Hydroxythiovardenafil was therefore suggested as a proprietary name for the new molecule. This is the first paper to describe a thio-analog of vardenafil in a commercially available product. |
|
dc.relation.ispartof |
urn:issn:0731-7085 |
|
dc.title |
Detection and structure elucidation of hydroxythiovardenafil as an adulterant in a herbal dietary supplement |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-11-16T18:02:41Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2159533 |
|
dc.identifier.wos |
000314332300012 |
|
dc.identifier.pubmed |
23245238 |
|
dc.contributor.department |
SE/GYTK/Gyógyszerészi Kémiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|