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dc.contributor.author Kovács, Gábor
dc.contributor.author Wachtel A
dc.contributor.author Basharova E
dc.contributor.author Spinelli T
dc.contributor.author Nicolas P
dc.contributor.author Kabickova E
dc.date.accessioned 2018-06-20T12:41:52Z
dc.date.available 2018-06-20T12:41:52Z
dc.date.issued 2017
dc.identifier 85028573236
dc.identifier.citation pagination=1685-1698; journalVolume=13; journalIssueNumber=19; journalTitle=FUTURE ONCOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5437
dc.identifier.uri doi:10.2217/fon-2017-0189
dc.description.abstract Aim: To investigate across multiple cycles the efficacy and safety of palonosetron in the prevention of chemotherapy-induced nausea and vomiting in pediatric cancer patients receiving highly or moderately emetogenic chemotherapy (HEC/MEC). Patients & methods: Patients were randomly assigned to 10, 20 mu g/kg palonosetron or 3 x 150 mu g/kg ondansetron for up to four cycles of HEC/MEC. Results: In all on-study chemotherapy cycles, complete response rates were higher in patients in the 20 mu g/kg palonosetron group than the ondansetron group. Treatment-emergent adverse events were comparable between the palonosetron 20 mu g/kg and ondansetron groups. Conclusion: Over four cycles of HEC/MEC, 20 mu g/kg palonosetron was an efficacious and safe treatment for the prevention of chemotherapy-induced nausea and vomiting in pediatric cancer patients.
dc.relation.ispartof urn:issn:1479-6694
dc.title Palonosetron compared with ondansetron in pediatric cancer patients: multicycle analysis of a randomized Phase III study
dc.type Journal Article
dc.date.updated 2018-05-14T13:33:46Z
dc.language.rfc3066 en
dc.identifier.mtmt 3341373
dc.identifier.wos 000409493600005
dc.identifier.pubmed 28569078
dc.contributor.department SE/AOK/K/II. Sz. Gyermekgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem


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