Determination of absolute configuration of ketamine enantiomers by HPLC-CD-UV technique

dc.contributor.author	Gergely András
dc.contributor.author	Zsila Ferenc
dc.contributor.author	Horváth Péter
dc.contributor.author	Szász György
dc.date.accessioned	2018-07-30T15:06:31Z
dc.date.available	2018-07-30T15:06:31Z
dc.date.issued	1999
dc.identifier.citation	pagination=741-744; journalVolume=11; journalIssueNumber=10; journalTitle=CHIRALITY: THE PHARMACOLOGICAL BIOLOGICAL AND CHEMICAL CONSEQUENCES OF MOLECULAR ASYMMETRY;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/5469
dc.identifier.uri	doi:10.1002/(SICI)1520-636X(1999)11:10<741::AID-CHIR1>3.0.CO;2-2
dc.description.abstract	Recognizing that the stereochemical structure of NMDA receptor antagonist ketamine provides valuable data about the relationship between its conformation and absolute configuration by CD-UV analysis, a method for the identification of ketamine enantiomers is proposed which avoids the need for authentic samples of the enantiomers. The ketamine enantiomers were separated by HPLC using Chiralcel OJ stationary phase. The in situ registration of CD and UV spectra, together with the application of the octant rule for cyclohexanone derivatives, makes possible the direct assignment of the eluted ketamine enantiomers.
dc.relation.ispartof	urn:issn:0899-0042
dc.title	Determination of absolute configuration of ketamine enantiomers by HPLC-CD-UV technique
dc.type	Journal Article
dc.date.updated	2018-05-28T07:02:49Z
dc.language.rfc3066	en
dc.identifier.mtmt	1071385
dc.identifier.wos	000083656000001
dc.identifier.pubmed	10561702
dc.contributor.department	SE/GYTK/Gyógyszerészi Kémiai Intézet
dc.contributor.institution	Semmelweis Egyetem