dc.contributor.author |
Könye Rita |
|
dc.contributor.author |
Tóth Gergő |
|
dc.contributor.author |
Sólyomváry Anna |
|
dc.contributor.author |
Mervai Zsolt |
|
dc.contributor.author |
Zürn M |
|
dc.contributor.author |
Baghy Kornélia |
|
dc.contributor.author |
Kovalszky Ilona |
|
dc.contributor.author |
Horváth Péter |
|
dc.contributor.author |
Perlné Molnár Ibolya |
|
dc.contributor.author |
Noszál Béla |
|
dc.contributor.author |
Béni Szabolcs |
|
dc.contributor.author |
Boldizsár Imre |
|
dc.date.accessioned |
2018-06-22T10:31:08Z |
|
dc.date.available |
2018-06-22T10:31:08Z |
|
dc.date.issued |
2018 |
|
dc.identifier |
85045559589 |
|
dc.identifier.citation |
pagination=413-419;
journalVolume=127;
journalTitle=FITOTERAPIA; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5491 |
|
dc.identifier.uri |
doi:10.1016/j.fitote.2018.04.007 |
|
dc.description.abstract |
While analyzing the fruit composition of nine European Cirsium species representing three sections (i.e., Cephalonoplos, Chamaeleon and Eriolepis), four lignans, three neolignans and three sesquineolignans were determined and used as chemotaxonomic markers. Among them, desmethyl balanophonin and desmethyl picrasmalignan were determined for the first time in the plant kingdom, as the main metabolites of the Chamaeleon section. Prebalanophonin and prepicrasmalignan, identified so far exclusively in C. eriophorum, were also confirmed in C. boujartii and C. vulgare, highlighting the chemotaxonomic significance of these compounds in the Eriolepis section. The antiproliferative assay of the compounds isolated from their optimum sources, confirmed a dose-dependent inhibitory effect of the structures bearing the 4′,7-epoxy moiety (balanophonin, picrasmalignan, desmethyl balanophonin, desmethyl picrasmalignan) against SW480 colon cancer cells, while those bearing the 4′,7-dihydroxy motif (prebalanophonin, prepicrasmalignan) were inactive. © 2018 Elsevier B.V. |
|
dc.relation.ispartof |
urn:issn:0367-326X |
|
dc.title |
Chemodiversity of Cirsium fruits: Antiproliferative lignans, neolignans and sesquineolignans as chemotaxonomic markers |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-05-29T12:13:08Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3368249 |
|
dc.contributor.department |
SE/GYTK/Farmakognózia Intézet |
|
dc.contributor.department |
SE/GYTK/Gyógyszerészi Kémiai Intézet |
|
dc.contributor.department |
SE/AOK/I/I. Sz. Patológiai és Kísérleti Rákkutató Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
FELTÖLTŐ: Reményi Zsuzsa - titkarsag@drog.sote.hu
N1 Article in Press |
|