Show simple item record Horvath, Eszter Mária Magenheim, Rita Domjan BA Ferencz, Viktória Tänczer, Tímea Szabo E Benkő, Rita Szabo C Tabák, Ádám Somogyi, Anikó 2018-06-19T09:41:26Z 2018-06-19T09:41:26Z 2015
dc.identifier 84947460274
dc.identifier.citation pagination=1932-1936; journalVolume=156; journalIssueNumber=47; journalTitle=ORVOSI HETILAP;
dc.identifier.uri doi:10.1556/650.2015.30307
dc.description.abstract INTRODUCTION: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. AIM: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. METHOD: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. RESULTS: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. CONCLUSIONS: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease. Orv. Hetil., 2015, 156(47), 1932-1936.
dc.relation.ispartof urn:issn:0030-6002
dc.title A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel
dc.type Journal Article 2018-06-13T15:14:21Z
dc.language.rfc3066 hu
dc.identifier.mtmt 2991119
dc.identifier.wos 000369855100012
dc.identifier.pubmed 26568110
dc.contributor.department SE/AOK/I/Élettani Intézet
dc.contributor.department SE/AOK/K/I. Sz. Belgyógyászati Klinika
dc.contributor.department SE/AOK/K/II. Sz. Belgyógyászati Klinika
dc.contributor.department SE/KSZE/Klinikai Kísérleti Kutató Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Dr. Somogyi Anikó és Dr. Tabák Ádám egyenlő mértékben vettek részt a tanulmány elkészítésében

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