Egyszerű nézet Tegze, Bálint Tulassay, Zsolt Győrffy, Balázs 2018-10-29T07:55:42Z 2018-10-29T07:55:42Z 2006
dc.identifier 34248579331
dc.identifier.citation pagination=315-323; journalVolume=50; journalIssueNumber=4; journalTitle=MAGYAR ONKOLÓGIA;
dc.description.abstract Colorectal carcinoma is one of the most common cancers in Hungary, responsible for about 5000 deaths each year. In the first line treatment the most commonly used drugs are 5-fluorouracil, oxaliplatin and irinotecan. The most frequently used drug is 5-fluorouracil, which has no effect in 90% of the cases. In combination with leukovorin or with 5-ethyl-2'-deoxyuridin fluorouracil has an increased effect. The main mechanisms of the resistance against 5-fluorouracil are due to the overexpression of dihydropyrimidine dehydrogenase, MRP8, thymidylate synthase, and NFkB p65. Oxaliplatin forms reactive platinum complexes, which are believed to inhibit DNA synthesis by forming interstrand and intrastrand cross-linking of DNA molecules. The oxaliplatin-5-fluorouracil-leucovorin combination was the first to reach more than 20 months median survival. The main mechanisms of resistance are decreased accumulation, increased detoxification and increased DNA repair. Irinotecan inhibits the topoisomerase I enzyme, resulting in the inhibition of the repair of DNA breaks occurring during DNA synthesis. With sequential 5-fluorouracil, oxaliplatin, irinotecan combination 26 months median survival was reached. Mechanisms resulting in resistance are decreased accumulation, increased enzymatic detoxification, alterations of ABC transporters, DNA repair system, apoptotic pathways and topoisomerase I. Survival can be elongated using biological therapy (cetuximab, bevacizumab). In the near future biological therapy is expected to spread.
dc.relation.ispartof urn:issn:0025-0244
dc.title Kemoterapeutikumok, terápiás válasz és reziztencia-mechanizmusok a colorectalis carcinoma kezelésében.
dc.type Journal Article 2018-07-06T10:24:14Z
dc.language.rfc3066 hu
dc.identifier.mtmt 1890525
dc.identifier.pubmed 17216005
dc.contributor.department SE/AOK/K/II. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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