Show simple item record Karády, Júlia Panajotu, Alexisz Kolossváry, Márton József Szilveszter, Bálint Jermendy, Ádám Levente Bartykowszki, Andrea Károlyi, Mihály Celeng, Csilla Merkely, Béla Péter Maurovich-Horvat, Pál 2018-08-09T13:32:42Z 2018-08-09T13:32:42Z 2017
dc.identifier 85019548247
dc.identifier.citation pagination=4538-4543; journalVolume=27; journalIssueNumber=11; journalTitle=EUROPEAN RADIOLOGY;
dc.identifier.uri doi:10.1007/s00330-017-4866-0
dc.description.abstract OBJECTIVES: Contrast media (CM) extravasation is a well-known complication of CT angiography (CTA). Our prospective randomized control study aimed to assess whether a four-phasic CM administration protocol reduces the risk of extravasation compared to the routinely used three-phasic protocol in coronary CTA. METHODS: Patients referred to coronary CTA due to suspected coronary artery disease were included in the study. All patients received 400 mg/ml iomeprol CM injected with dual-syringe automated injector. Patients were randomized into a three-phasic injection-protocol group, with a CM bolus of 85 ml followed by 40 ml of 75%:25% saline/CM mixture and 30 ml saline chaser bolus; and a four-phasic injection-protocol group, with a saline pacer bolus of 10 ml injected at a lower flow rate before the three-phasic protocol. RESULTS: 2,445 consecutive patients were enrolled (mean age 60.6 +/- 12.1 years; females 43.6%). Overall rate of extravasation was 0.9% (23/2,445): 1.4% (17/1,229) in the three-phasic group and 0.5% (6/1,216) in the four-phasic group (p = 0.034). CONCLUSIONS: Four-phasic CM administration protocol is easy to implement in the clinical routine at no extra cost. The extravasation rate is reduced by 65% with the application of the four-phasic protocol compared to the three-phasic protocol in coronary CTA. KEY POINTS: * Four-phasic CM injection-protocol reduces extravasation rate by 65% compared to three-phasic. * The saline pacer bolus substantially reduces the risk of CM extravasation. * The implementation of four-phasic injection-protocol is at no cost.
dc.relation.ispartof urn:issn:0938-7994
dc.title The effect of four-phasic versus three-phasic contrast media injection protocols on extravasation rate in coronary CT angiography: a randomized controlled trial.
dc.type Journal Article 2018-07-13T06:38:37Z
dc.language.rfc3066 en
dc.identifier.mtmt 3231069
dc.identifier.wos WOS:000412820500011
dc.identifier.pubmed 28540480
dc.contributor.department SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék [2017.10.31]
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Drs. Júlia Karády, Alexisz Panajotu, Béla Merkely and Pál Maurovich-Horvat contributed equally to this work.

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