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dc.contributor.author Karády, Júlia
dc.contributor.author Panajotu, Alexisz
dc.contributor.author Kolossváry, Márton József
dc.contributor.author Szilveszter, Bálint
dc.contributor.author Jermendy, Ádám Levente
dc.contributor.author Bartykowszki, Andrea
dc.contributor.author Károlyi, Mihály
dc.contributor.author Celeng, Csilla
dc.contributor.author Merkely, Béla Péter
dc.contributor.author Maurovich-Horvat, Pál
dc.date.accessioned 2018-08-09T13:32:42Z
dc.date.available 2018-08-09T13:32:42Z
dc.date.issued 2017
dc.identifier 85019548247
dc.identifier.citation pagination=4538-4543; journalVolume=27; journalIssueNumber=11; journalTitle=EUROPEAN RADIOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5768
dc.identifier.uri doi:10.1007/s00330-017-4866-0
dc.description.abstract OBJECTIVES: Contrast media (CM) extravasation is a well-known complication of CT angiography (CTA). Our prospective randomized control study aimed to assess whether a four-phasic CM administration protocol reduces the risk of extravasation compared to the routinely used three-phasic protocol in coronary CTA. METHODS: Patients referred to coronary CTA due to suspected coronary artery disease were included in the study. All patients received 400 mg/ml iomeprol CM injected with dual-syringe automated injector. Patients were randomized into a three-phasic injection-protocol group, with a CM bolus of 85 ml followed by 40 ml of 75%:25% saline/CM mixture and 30 ml saline chaser bolus; and a four-phasic injection-protocol group, with a saline pacer bolus of 10 ml injected at a lower flow rate before the three-phasic protocol. RESULTS: 2,445 consecutive patients were enrolled (mean age 60.6 +/- 12.1 years; females 43.6%). Overall rate of extravasation was 0.9% (23/2,445): 1.4% (17/1,229) in the three-phasic group and 0.5% (6/1,216) in the four-phasic group (p = 0.034). CONCLUSIONS: Four-phasic CM administration protocol is easy to implement in the clinical routine at no extra cost. The extravasation rate is reduced by 65% with the application of the four-phasic protocol compared to the three-phasic protocol in coronary CTA. KEY POINTS: * Four-phasic CM injection-protocol reduces extravasation rate by 65% compared to three-phasic. * The saline pacer bolus substantially reduces the risk of CM extravasation. * The implementation of four-phasic injection-protocol is at no cost.
dc.relation.ispartof urn:issn:0938-7994
dc.title The effect of four-phasic versus three-phasic contrast media injection protocols on extravasation rate in coronary CT angiography: a randomized controlled trial.
dc.type Journal Article
dc.date.updated 2018-07-13T06:38:37Z
dc.language.rfc3066 en
dc.identifier.mtmt 3231069
dc.identifier.wos WOS:000412820500011
dc.identifier.pubmed 28540480
dc.contributor.department SE/AOK/K/Városmajori Szív- és Érgyógyászati Klinika
dc.contributor.department SE/AOK/K/VAROSMAJOR_SZÍVÉRGYÓGY/Kardiológia Központ - Kardiológiai Tanszék [2017.10.31]
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Drs. Júlia Karády, Alexisz Panajotu, Béla Merkely and Pál Maurovich-Horvat contributed equally to this work.


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