dc.contributor.author |
Varjú, Péter |
|
dc.contributor.author |
Borbásné Farkas, Kornélia |
|
dc.contributor.author |
Hegyi, Péter |
|
dc.contributor.author |
Garami, András |
|
dc.contributor.author |
Szabó, Imre |
|
dc.contributor.author |
Illés, Anita |
|
dc.contributor.author |
Szekeres-Solymár, Margit |
|
dc.contributor.author |
Vincze, Áron |
|
dc.contributor.author |
Balaskó, Márta |
|
dc.contributor.author |
Pár, Gabriella |
|
dc.contributor.author |
Bajor, Judit |
|
dc.contributor.author |
Szűcs, Ákos |
|
dc.contributor.author |
Huszar O |
|
dc.contributor.author |
Pécsi, Dániel |
|
dc.contributor.author |
Czimmer, József |
|
dc.date.accessioned |
2018-09-17T06:35:37Z |
|
dc.date.available |
2018-09-17T06:35:37Z |
|
dc.date.issued |
2017 |
|
dc.identifier |
85028560744 |
|
dc.identifier.citation |
pagination=e0182942, pages: 15;
journalVolume=12;
journalIssueNumber=8;
journalTitle=PLOS ONE; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/5968 |
|
dc.identifier.uri |
doi:10.1371/journal.pone.0182942 |
|
dc.description.abstract |
BACKGROUND: Irritable bowel syndrome (IBS) and functional digestive tract disorders, e.g. functional bloating, carbohydrate maldigestion and intolerances, are very common disorders frequently causing significant symptoms that challenge health care systems. A low Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) diet is one of the possible therapeutic approaches for decreasing abdominal symptoms and improving quality of life. OBJECTIVES: We aimed to meta-analyze data on the therapeutic effect of a low-FODMAP diet on symptoms of IBS and quality of life and compare its effectiveness to a regular, standard IBS diet with high FODMAP content, using a common scoring system, the IBS Symptom Severity Score (IBS-SSS). METHODS: A systematic literature search was conducted in PubMed, EMBASE and the Cochrane Library as well as in the references in a recent meta-analysis. Adult patients diagnosed with IBS according to the Rome II, Rome III, Rome IV or NICE criteria were included in the analysis. STATISTICAL METHODS: Mean differences with 95% confidence intervals were calculated from studies that contained means, standard deviation (SD) or mean differences and SD of differences and p-values. A random effect model was used because of the heterogeneity (Q test (chi2) and I2 indicator). A p-value of less than 0.05 was chosen to indicate a significant difference. RESULTS: The literature search yielded 902 publications, but only 10 were eligible for our meta-analysis. Both regular and low-FODMAP diets proved to be effective in IBS, but post-diet IBS-SSS values were significantly lower (p = 0.002) in the low-FODMAP group. The low-FODMAP diet showed a correlation with the improvement of general symptoms (by IBS-SSS) in patients with IBS. CONCLUSIONS: This meta-analysis provides high-grade evidence of an improved general symptom score among patients with irritable bowel syndrome who have maintained a low-FODMAP diet compared to those on a traditional IBS diet, therefore showing its superiority to regular IBS dietary therapy. These data suggest that a low-FODMAP diet with dietitian control can be a candidate for first-line therapeutic modality in IBS. Because of a lack of data, well-planned randomized controlled studies are needed to ascertain the correlation between improvement of separate key IBS symptoms and the effect of a low-FODMAP diet. |
|
dc.relation.ispartof |
urn:issn:1932-6203 |
|
dc.title |
Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to standard IBS diet: A meta-analysis of clinical studies |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-07-20T06:49:28Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3255862 |
|
dc.identifier.wos |
000407548800037 |
|
dc.identifier.pubmed |
28806407 |
|
dc.contributor.department |
PTE/Szentágothai János Kutatóközpont |
|
dc.contributor.department |
SZTE/ÁOK/I.BelK/MTA-SZTE Lendület Gasztroenterológiai Multidiszciplináris Kutatócsoport |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Sebészeti Klinika |
|
dc.contributor.institution |
Pécsi Tudományegyetem |
|
dc.contributor.institution |
Szegedi Tudományegyetem |
|
dc.contributor.institution |
Semmelweis Egyetem |
|