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dc.contributor.author Juhász, János
dc.contributor.author Kertesz-Farkas A
dc.contributor.author Szabó, Dóra
dc.contributor.author Pongor, Sándor
dc.date.accessioned 2018-09-13T06:27:38Z
dc.date.available 2018-09-13T06:27:38Z
dc.date.issued 2014
dc.identifier 84899701360
dc.identifier.citation pagination=e95511, pages: 9; journalVolume=9; journalIssueNumber=4; journalTitle=PLOS ONE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/5986
dc.identifier.uri doi:10.1371/journal.pone.0095511
dc.description.abstract Multispecies bacterial communities such as the microbiota of the gastrointestinal tract can be remarkably stable and resilient even though they consist of cells and species that compete for resources and also produce a large number of antimicrobial agents. Computational modeling suggests that horizontal transfer of resistance genes may greatly contribute to the formation of stable and diverse communities capable of protecting themselves with a battery of antimicrobial agents while preserving a varied metabolic repertoire of the constituent species. In other words horizontal transfer of resistance genes makes a community compatible in terms of exoproducts and capable to maintain a varied and mature metagenome. The same property may allow microbiota to protect a host organism, or if used as a microbial therapy, to purge pathogens and restore a protective environment.
dc.relation.ispartof urn:issn:1932-6203
dc.title Emergence of Collective Territorial Defense in Bacterial Communities: Horizontal Gene Transfer Can Stabilize Microbiomes
dc.type Journal Article
dc.date.updated 2018-07-20T07:28:49Z
dc.language.rfc3066 en
dc.identifier.mtmt 2603417
dc.identifier.wos 000335240300049
dc.identifier.pubmed 24755769
dc.contributor.department SE/AOK/I/Orvosi Mikrobiológiai Intézet
dc.contributor.institution Semmelweis Egyetem
dc.mtmt.swordnote Juhasz J and Kertesz-Farkas A contributed equally to this work.


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