dc.contributor.author |
Temesszentandrási, György |
|
dc.contributor.author |
Vörös, Krisztián |
|
dc.contributor.author |
Márkus, Bernadett |
|
dc.contributor.author |
Böröcz, Zoltán |
|
dc.contributor.author |
Kaszas E |
|
dc.contributor.author |
Prohászka, Zoltán |
|
dc.contributor.author |
Falus, András |
|
dc.contributor.author |
Cseh, Károly |
|
dc.contributor.author |
Kalabay, László |
|
dc.date.accessioned |
2018-09-04T11:54:46Z |
|
dc.date.available |
2018-09-04T11:54:46Z |
|
dc.date.issued |
2016 |
|
dc.identifier |
84983460257 |
|
dc.identifier.citation |
pagination=2742-2750;
journalVolume=22;
journalTitle=MEDICAL SCIENCE MONITOR; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6037 |
|
dc.identifier.uri |
doi:10.12659/MSM.896232 |
|
dc.description.abstract |
BACKGROUND Human fetuin A (AHSG) has been associated with the development of obesity, insulin resistance, type 2 diabetes mellitus, and atherosclerosis. Observations on the role of AHSG rs4918 single-nucleotide polymorphism are contradictory. We investigated the association between variants of rs4918 and parameters of obesity, lipid status, tumor necrosis factor-alpha (TNFalpha), adipokines (adiponectin, resistin, leptin), and insulin resistance in healthy persons and in patients with previous myocardial infarction. MATERIAL AND METHODS This was a cross-sectional study comprising cohort 1 (81 healthy individuals) and cohort 2 (157 patients with previous myocardial infarction). We used the allele-specific KASP genotyping assay to detect rs4918 polymorphism. RESULTS In cohort 1, G-nucleotide carriers had significantly lower serum TNFalpha, adiponectin, and higher leptin concentrations than in non-G carriers. These differences, however, were not observed in cohort 2. In cohort 2, G-carriers had lower BMI and waist circumferences than in non-G carriers. The G allele was more frequent among lean than obese patients (RR=1.067, 95%CI=1.053-2.651, p=0.015). An association between BMI and rs4918 polymorphism was observed among patients without diabetes (CC/CG/GG genotypes: p=0.003, G vs. non-G allele: p=0.008) but not in diabetics. In addition, a strong linearity between BMI and the CC/CG/GG genotypes (association value: 4.416, p=0.036) and the frequency of the G allele (7.420, p=0.006) could be identified. In cohort 2, non-obese, non-diabetic G-carriers still had lower BMI and waist circumferences than in non-G carriers. CONCLUSIONS The rs4918 minor variant is associated with lower TNFalpha and adiponectin, higher leptin levels in healthy persons, and more favorable anthropomorphic parameters of obesity in cohort 2. |
|
dc.relation.ispartof |
urn:issn:1234-1010 |
|
dc.title |
Human Fetuin-A Rs4918 Polymorphism and its Association with Obesity in Healthy Persons and in Patients with Myocardial Infarction in Two Hungarian Cohorts. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-08-02T13:22:39Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3103196 |
|
dc.identifier.wos |
000381308800001 |
|
dc.identifier.pubmed |
27487851 |
|
dc.contributor.department |
SE/AOK/K/III. Sz. Belgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/Családorvosi Tanszék |
|
dc.contributor.department |
SE/AOK/I/Genetikai, Sejt- és Immunbiológiai Intézet |
|
dc.contributor.department |
SE/AOK/I/Népegészségtani Intézet |
|