dc.contributor.author |
Galderisi S, |
|
dc.contributor.author |
Mucci A, |
|
dc.contributor.author |
Bitter, István |
|
dc.contributor.author |
Libiger J, |
|
dc.contributor.author |
Bucci P, |
|
dc.date.accessioned |
2014-12-05T08:51:57Z |
|
dc.date.available |
2014-12-05T08:51:57Z |
|
dc.date.issued |
2013 |
|
dc.identifier |
84875268666 |
|
dc.identifier.citation |
pagination=196-204;
journalVolume=23;
journalIssueNumber=3;
journalTitle=EUROPEAN NEUROPSYCHOPHARMACOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/607 |
|
dc.identifier.uri |
doi:10.1016/j.euroneuro.2012.04.019 |
|
dc.description.abstract |
Negative symptoms that do not improve following antipsychotic treatment represent a challenge for development of effective treatments. Few studies have been carried out so far, especially in first-episode schizophrenia patients, to clarify prevalence, correlates and impact of persistent negative symptoms (PNS) on short- and long-term outcome of the disease. All patients from EUFEST study for whom both baseline and 12-month assessments were available were included (N=345). PNS were defined as the presence of at least one negative symptom of moderate or higher severity, not confounded by depression or parkinsonism, at baseline and after 1 year of treatment. Patients with PNS were compared to those with at least one negative symptom of moderate or higher severity at the baseline, not persisting after 1 year, on demographic, clinical, neurocognitive, global functioning and quality of life measures. PNS not confounded by depression or parkinsonism were present in 6.7% of the sample. The symptom that more often persisted was blunted affect. Patients with PNS differed from those without PNS for a longer duration of untreated psychosis (DUP) and a more frequent discontinuation of study treatment; they also had a poorer psychopathological outcome and a worse global functioning after 1 year of treatment. The presence of PNS was associated to poorer improvement of all psychopathological dimensions and worse global functioning after 1 year of treatment. The longer DUP in subjects with PNS suggests that programs aimed at shortening DUP might reduce the prevalence of PNS and improve prognosis of schizophrenia. |
|
dc.relation.ispartof |
urn:issn:0924-977X |
|
dc.title |
Persistent negative symptoms in first episode patients with schizophrenia: Results from the European First Episode Schizophrenia Trial. |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-12-01T08:28:16Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2098297 |
|
dc.identifier.wos |
000316436900003 |
|
dc.identifier.pubmed |
22647933 |
|
dc.contributor.department |
SE/ÁOK/K/Pszichiátriai és Pszichoterápiás Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|