dc.contributor.author |
Hulman A, |
|
dc.contributor.author |
Tabák, Ádám |
|
dc.contributor.author |
Nyari TA, |
|
dc.contributor.author |
Vistisen D, |
|
dc.contributor.author |
Kivimaki M, |
|
dc.contributor.author |
Brunner EJ |
|
dc.contributor.author |
Witte DR |
|
dc.date.accessioned |
2014-12-07T19:03:09Z |
|
dc.date.available |
2014-12-07T19:03:09Z |
|
dc.date.issued |
2014 |
|
dc.identifier |
84902689589 |
|
dc.identifier.citation |
pagination=866-877;
journalVolume=43;
journalIssueNumber=3;
journalTitle=INTERNATIONAL JOURNAL OF EPIDEMIOLOGY; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/614 |
|
dc.identifier.uri |
doi:10.1093/ije/dyt279 |
|
dc.description.abstract |
BACKGROUND:: Secular trends in cardiovascular risk factors have been described, but few studies have examined simultaneously the effects of both ageing and secular trends within the same cohort. METHODS:: Development of cardiovascular risk factors over the past three decades was analysed using serial measurements from 10 308 participants aged from 35 to 80 years over 25 years of follow-up from five clinical examination phases of the Whitehall II study. Changes of body mass index, waist circumference, blood pressure and total and high-density lipoprotein cholesterol distribution characteristics were analysed with quantile regression models in the 57-61 age group. Age-related trajectories of risk factors were assessed by fitting mixed-effects models with adjustment for year of birth to reveal secular trends. RESULTS:: Average body mass index and waist circumference increased faster with age in women than in men, but the unfavourable secular trend was more marked in men. Distributions showed a fattening of the right tail in each consecutive phase, meaning a stronger increase in higher percentiles. Despite the higher obesity levels in younger birth cohorts, total cholesterol decreased markedly in the 57-61 age group along the entire distribution rather than in higher extremes only. CONCLUSION:: The past three decades brought strong and heterogeneous changes in cardiovascular risk factor distributions. Secular trends appear to modify age-related trajectories of cardiovascular risk factors, which may be a source of bias in longitudinal analyses. |
|
dc.relation.ispartof |
urn:issn:0300-5771 |
|
dc.title |
Effect of secular trends on age-related trajectories of cardiovascular risk factors: the Whitehall II longitudinal study 1985-2009 |
|
dc.type |
Journal Article |
|
dc.date.updated |
2014-12-02T09:09:48Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
2567006 |
|
dc.identifier.wos |
000338127000030 |
|
dc.identifier.pubmed |
24464190 |
|
dc.contributor.department |
SE/ÁOK/K/I. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|