dc.contributor.author |
Vannay, Ádám |
|
dc.contributor.author |
Vásárhelyi, Barna |
|
dc.contributor.author |
Kornyei M, |
|
dc.contributor.author |
Treszl, András |
|
dc.contributor.author |
Kozma G, |
|
dc.contributor.author |
Győrffy, Balázs |
|
dc.contributor.author |
Tulassay, Tivadar |
|
dc.contributor.author |
Sulyok, Endre |
|
dc.date.accessioned |
2018-10-08T07:32:15Z |
|
dc.date.available |
2018-10-08T07:32:15Z |
|
dc.date.issued |
2006 |
|
dc.identifier |
33645226790 |
|
dc.identifier.citation |
pagination=878-881;
journalVolume=151;
journalIssueNumber=4;
journalTitle=AMERICAN HEART JOURNAL; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6279 |
|
dc.identifier.uri |
doi:10.1016/j.ahj.2005.10.012 |
|
dc.description.abstract |
Background: Disturbed vascular endothelial growth factor (VEGF) production during early heart morphogenesis causes endocardial cushion malformation, which results in congenital heart disease (CHD). We tested whether functional VEGF -460T/C and +405G/C polymorphisms that have an impact on VEGF levels were associated with CHD. Methods: Dried blood samples were collected from 102 CHD children and 112 healthy control neonates. Genotyping was done with polymerase chain reaction-restriction fragment length polymorphism (VEGF +405G/C) and real-time polymerase chain reaction methods (VEGF -460T/C). Results: VEGF -460C allele frequency was similar in control and CHD subjects. VEGF +405C allele was less prevalent in controls than in CHD subjects (0.21 vs 0.42, P <.001). Having VEGF +405C presented increased risk for CHD (odds ratio [OR] 1.72, 95% CI 1.32-2.26). VEGF -460CT/+405CC allele associations did not occur in controls but in CHD patients (0% vs 13%, OR 2.26, 95% CI 1.93-2.64), whereas -460CT/+405GG allele association was more prevalent in controls (32% vs 16%, OR 0.58, 95% CI 0.37-0.89). Conclusions: VEGF gene and allele associations may be associated with increased risk of CHID. |
|
dc.relation.ispartof |
urn:issn:0002-8703 |
|
dc.title |
Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-08-31T05:59:26Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1177619 |
|
dc.identifier.wos |
000236721000027 |
|
dc.identifier.pubmed |
16569553 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/ISZGYK/MTA-SE Gyermekgyógyászati és Nephrológiai Kutatócsoport |
|
dc.contributor.institution |
Semmelweis Egyetem |
|
dc.mtmt.swordnote |
Ádám Vannay and Barna Vásárhelyi have equally contributed to this work. |
|