Egyszerű nézet Várbíró, Szabolcs Biró, Adrienn Cervenak, Judit Cervenak, László Singh M Bánhidy, Ferenc Sebestyen A Füst, György Prohászka, Zoltán 2018-10-11T07:00:43Z 2018-10-11T07:00:43Z 2010
dc.identifier 77949547555
dc.identifier.citation pagination=1-10; journalVolume=97; journalIssueNumber=1; journalTitle=ACTA PHYSIOLOGICA HUNGARICA;
dc.identifier.uri doi:10.1556/APhysiol.97.2010.1.1
dc.description.abstract Anti-human Hsp60 autoantibodies--known risk factor of atherosclerosis--were investigated in a mouse model and in samples of healthy subjects: polyreactivity, presence in cord blood samples of healthy newborns and life-long stability were tested. In IgM hybridoma panel from mouse spleens, polyreactivity of anti-Hsp60 autoantibodies was studied. In healthy pregnant women, umbilical vein and maternal blood samples were collected after childbirth, anti-Hsp-60 and -65 IgM and IgG levels were measured. Life-long stability of anti-Hsp-60 levels was studied on healthy patients during 5 years. ELISA was used in all studies. Polyreactivity of IgM clones of newborn mice and lifelong stability of these autoantibodies in healthy adults were established. IgM anti-Hsp60 autoantibodies in cord blood of healthy human infants were present, however, there was no correlation between maternal and cord blood IgM anti-Hsp60 concentrations. It is proposed that presence of anti-Hsp60 autoantibodies--as part of the natural autoantibody repertoire--may be an inherited trait. Level of anti-Hsp60 autoantibodies may be an independent, innate risk factor of atherosclerosis for the adulthood.
dc.relation.ispartof urn:issn:0231-424X
dc.title Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies
dc.type Journal Article 2018-09-02T10:04:43Z
dc.language.rfc3066 en
dc.identifier.mtmt 1354885
dc.identifier.wos 000275644800001
dc.identifier.pubmed 20233685
dc.contributor.department Semmelweis Egyetem
dc.contributor.department SE/AOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

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