dc.contributor.author |
Várbíró, Szabolcs |
|
dc.contributor.author |
Biró, Adrienn |
|
dc.contributor.author |
Cervenak, Judit |
|
dc.contributor.author |
Cervenak, László |
|
dc.contributor.author |
Singh M |
|
dc.contributor.author |
Bánhidy, Ferenc |
|
dc.contributor.author |
Sebestyen A |
|
dc.contributor.author |
Füst, György |
|
dc.contributor.author |
Prohászka, Zoltán |
|
dc.date.accessioned |
2018-10-11T07:00:43Z |
|
dc.date.available |
2018-10-11T07:00:43Z |
|
dc.date.issued |
2010 |
|
dc.identifier |
77949547555 |
|
dc.identifier.citation |
pagination=1-10;
journalVolume=97;
journalIssueNumber=1;
journalTitle=ACTA PHYSIOLOGICA HUNGARICA; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6380 |
|
dc.identifier.uri |
doi:10.1556/APhysiol.97.2010.1.1 |
|
dc.description.abstract |
Anti-human Hsp60 autoantibodies--known risk factor of atherosclerosis--were investigated in a mouse model and in samples of healthy subjects: polyreactivity, presence in cord blood samples of healthy newborns and life-long stability were tested. In IgM hybridoma panel from mouse spleens, polyreactivity of anti-Hsp60 autoantibodies was studied. In healthy pregnant women, umbilical vein and maternal blood samples were collected after childbirth, anti-Hsp-60 and -65 IgM and IgG levels were measured. Life-long stability of anti-Hsp-60 levels was studied on healthy patients during 5 years. ELISA was used in all studies. Polyreactivity of IgM clones of newborn mice and lifelong stability of these autoantibodies in healthy adults were established. IgM anti-Hsp60 autoantibodies in cord blood of healthy human infants were present, however, there was no correlation between maternal and cord blood IgM anti-Hsp60 concentrations. It is proposed that presence of anti-Hsp60 autoantibodies--as part of the natural autoantibody repertoire--may be an inherited trait. Level of anti-Hsp60 autoantibodies may be an independent, innate risk factor of atherosclerosis for the adulthood. |
|
dc.relation.ispartof |
urn:issn:0231-424X |
|
dc.title |
Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-09-02T10:04:43Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1354885 |
|
dc.identifier.wos |
000275644800001 |
|
dc.identifier.pubmed |
20233685 |
|
dc.contributor.department |
Semmelweis Egyetem |
|
dc.contributor.department |
SE/AOK/K/II. Sz. Szülészeti és Nőgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|