Egyszerű nézet Santos PSC Füst, György Prohászka, Zoltán Volz A Horton R Miretti M Yu CY Beck S Uchanska-Ziegler B Ziegler A 2018-10-11T12:31:22Z 2018-10-11T12:31:22Z 2008
dc.identifier.citation pagination=481-486; journalVolume=12; journalIssueNumber=4; journalTitle=GENETIC TESTING;
dc.identifier.uri doi:10.1089/gte.2008.0029
dc.description.abstract Smoking behavior has been associated in two independent European cohorts with the most common Caucasian human leukocyte antigen (HLA) haplotype (A1-B8-DR3). We aimed to test whether polymorphic members of the two odorant receptor (OR) clusters within the extended HLA complex might be responsible for the observed association, by genotyping a cohort of Hungarian women in which the mentioned association had been found. One hundred and eighty HLA haplotypes from Centre d'Etude du Polymorphisme Humain families were analyzed in silico to identify single-nucleotide polymorphisms (SNPs) within OR genes that are in linkage disequilibrium with the A1-B8-DR3 haplotype, as well as with two other haplotypes indirectly linked to smoking behavior. A nonsynonymous SNP within the OR12D3 gene (rs3749971(T)) was found to be linked to the A1-B8-DR3 haplotype. This polymorphism leads to a (97)Thr --> Ile exchange that affects a putative ligand binding region of the OR12D3 protein. Smoking was found to be associated in the Hungarian cohort with the rs3749971(T) allele (p = 1.05 x 10(-2)), with higher significance than with A1-B8-DR3 (p = 2.38 x 10(-2)). Our results link smoking to a distinct OR allele, and demonstrate that the rs3749971(T) polymorphism is associated with the HLA haplotype-dependent differential recognition of cigarette smoke components, at least among Caucasian women.
dc.relation.ispartof urn:issn:1090-6576
dc.title Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex.
dc.type Journal Article 2018-09-02T10:18:05Z
dc.language.rfc3066 en
dc.identifier.mtmt 1233476
dc.identifier.wos 000261730600004
dc.identifier.pubmed 18939942
dc.contributor.department SE/AOK/K/III. Sz. Belgyógyászati Klinika
dc.contributor.institution Semmelweis Egyetem

Kapcsolódó fájlok:

A fájl jelenleg csak egyetemi IP címről érhető el.


Ez a rekord az alábbi gyűjteményekben szerepel:

Egyszerű nézet