dc.contributor.author |
Molvarec, Attila |
|
dc.contributor.author |
Jermendy, Ágnes |
|
dc.contributor.author |
Kovacs M |
|
dc.contributor.author |
Prohászka, Zoltán |
|
dc.contributor.author |
Rigó, János Jr. |
|
dc.date.accessioned |
2018-10-10T09:22:39Z |
|
dc.date.available |
2018-10-10T09:22:39Z |
|
dc.date.issued |
2008 |
|
dc.identifier |
46049086761 |
|
dc.identifier.citation |
pagination=859-864;
journalVolume=31;
journalIssueNumber=5;
journalTitle=HYPERTENSION RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6394 |
|
dc.identifier.uri |
doi:10.1291/hypres.31.859 |
|
dc.description.abstract |
Preeclampsia is a multifactorial disorder with genetic and
environmental components. As Toll-like receptor 4 (TLR4) has an
essential role in innate immune response, which is exaggeratedly
activated in preeclampsia, our aim was to investigate whether
two single nucleotide polymorphisms (SNPs) of the TLR4 gene -
Asp299Gly (A896G) and Thr399lle (C1196T) - are associated with
preeclampsia in a Caucasian population from Hungary. In a case-
control study, we analyzed blood samples from 180 preeclamptic
patients and 172 normotensive, healthy pregnant women with the
polymerase chain reaction (PCR)-restriction fragment length
polymorphism (RFLP) method. The linkage disequilibrium (LD)
profile of the TLR4 gene was investigated and tag SNPs were
identified using data from the International HapMap Project.
There were no significant differences in the genotype and allele
frequencies of Asp299Gly and Thr399lle polymorphisms between the
two study groups. Additionally, no significant difference was
found in the distribution of the estimated haplotypes created by
the two polymorphisms between the preeclamptic and the control
group. Furthermore, no significant differences were detected in
the genotype, allele and haplotype frequencies of Asp299Gly and
Thr399lle TLR4 SNPs between patients with mild and severe
preeclampsia, between patients with late and early onset of the
disease, or between preeclamptic patients with and without fetal
growth restriction. In conclusion, We did not find an
association between TLR4 Asp299Gly and Thr399lle gene
polymorphisms and preeclampsia. As the Thr399lle polymorphism is
a highly informative tag SNP of the TLR4 gene, our results
suggest that variations in this genomic region are not
associated with preeclampsia. Nevertheless, further studies are
required with determination of fetal TLR4 genotypes to explore
the role of TLR4 gene polymorphisms in the risk of preeclampsia,
especially in ethnically different populations. |
|
dc.relation.ispartof |
urn:issn:0916-9636 |
|
dc.title |
Toll-like receptor 4 gene polymorphisms and preeclampsia: Lack of association in a Caucasian population |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-09-02T10:29:32Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
1132252 |
|
dc.identifier.wos |
000258391600005 |
|
dc.identifier.pubmed |
18712040 |
|
dc.contributor.department |
SE/AOK/K/I. Sz. Gyermekgyógyászati Klinika |
|
dc.contributor.department |
SE/AOK/K/III. Sz. Belgyógyászati Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|