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dc.contributor.author Birtalan, Ede
dc.contributor.author Dános, Kornél
dc.contributor.author Gurbi, Bianka
dc.contributor.author Brauswetter, Diána
dc.contributor.author Halász, Judit
dc.contributor.author Ács, Balázs
dc.contributor.author Antal B
dc.contributor.author Mihalyi R
dc.contributor.author Pató, Anna
dc.contributor.author Fent Z
dc.contributor.author Polony, Gábor
dc.contributor.author Tímár, József
dc.contributor.author Tamás, László
dc.date.accessioned 2018-10-02T09:43:42Z
dc.date.available 2018-10-02T09:43:42Z
dc.date.issued 2018
dc.identifier.citation pagination=E79-E85; journalVolume=26; journalIssueNumber=7; journalTitle=APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/6415
dc.identifier.uri doi:10.1097/PAI.0000000000000590
dc.description.abstract Despite great enthusiasm towards immunotherapy, reliable biomarkers are still lacking. The importance of subsets based on human papillomavirus (HPV) status is supported by a growing body of evidence. However, role of other possible subgroups such as anatomic localization of primary tumor remains controversial. Our objective was to investigate immune cell infiltrate and checkpoint inhibitor proteins in above-mentioned head and neck cancer subsets. Archival tumor samples of 106 laryngeal, oropharyngeal, and hypopharyngeal cancer patients were stained with PD-L1, PD-L2, PD-1, and CTLA-4 antibodies. Proportion of tumor-infiltrating lymphocytes was assessed as well. In HPV-negative tumors, PD-L1 immune cell positivity was associated with better disease-specific survival. PD-L1 expression on immune cells correlated with improved disease-specific survival in laryngeal tumors. Furthermore, PD-L1 immune cell positivity correlated with CTLA-4 expression on immune cells and it was accompanied by high tumor-infiltrating lymphocyte rate. PD-L1 expression on tumor cells and PD-1 status showed strong correlation in all patients and in oropharyngeal and laryngeal localization, but not in hypopharynx. HPV-negative oropharyngeal cancers showed negative PD-L1 status on tumor cells. CTLA-4 positivity was observed in 49.5% and 20.6% on immune cells and on tumor cells, respectively. We concluded that PD-L1 expression on immune cells indicates better prognosis in laryngeal squamous cell carcinoma and in HPV-negative head and neck squamous cell carcinoma. We have not found any essential differences between anatomic subgroups. A possibly distinct role of hypopharyngeal localization regarding immune activity requires further clarification.
dc.relation.ispartof urn:issn:1541-2016
dc.title Expression of PD-L1 on Immune Cells Shows Better Prognosis in Laryngeal, Oropharygeal, and Hypopharyngeal Cancer
dc.type Journal Article
dc.date.updated 2018-09-05T08:53:55Z
dc.language.rfc3066 en
dc.identifier.mtmt 3310542
dc.identifier.wos WOS:000441451500001
dc.identifier.pubmed 29271789
dc.contributor.department SE/AOK/K/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika
dc.contributor.institution Semmelweis Egyetem


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