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dc.contributor.author Horváth, András Attila
dc.contributor.author Szűcs, Anna
dc.contributor.author Hidasi, Zoltán
dc.contributor.author Csukly, Gábor
dc.contributor.author Barcs, Gábor
dc.contributor.author Kamondi, Anita
dc.date.accessioned 2018-10-02T09:45:10Z
dc.date.available 2018-10-02T09:45:10Z
dc.date.issued 2018
dc.identifier 85047369572
dc.identifier.citation pagination=1045-1054; journalVolume=63; journalIssueNumber=3; journalTitle=JOURNAL OF ALZHEIMER'S DISEASE;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/6497
dc.identifier.uri doi:10.3233/JAD-170925
dc.description.abstract BACKGROUND: Alzheimer's disease (AD) is the primary cause of cognitive decline. A growing body of evidence suggests that AD patients have a higher risk to develop epileptic seizures; however, results are contradictory due to different methodological approaches of previous studies. OBJECTIVE: We aimed to identify the prevalence, semiology, and risk factors of epilepsy in AD using long-term EEG. METHODS: We selected forty-two AD patients and examined them using 24-hour ambulatory EEG. Neurological and epileptological data were collected with retro- and prospective methods. We analyzed the semiology of the identified seizures and the possible risk factors using logistic regression analysis. RESULTS: We identified seizures confirmed by EEG in 24%. The majority of the seizures were aware focal (72%) without any motor activity (55%). We found epileptiform discharges without seizures in 28%. Patients with seizures and only with epileptic EEG activity showed similar clinical and demographical features. Higher education (OR:1.8) and lower Addenbrooke Examination Score (OR: 0.9) were identified as risk factors of epilepsy. Increase of 0.1 point in the Verbal-Language/Orientation-Memory ratio (VLOM) was associated with higher epilepsy risk as well (OR:2.9). CONCLUSION: Epilepsy is a frequent comorbidity of AD. Since most of the seizures are aware non-motor focal seizures, sensitive EEG techniques are required for precise diagnosis of epilepsy. Long-term ambulatory EEG is a safe and well-tolerated option. Epileptiform EEG in AD signals the presence of concomitant epilepsy. Clinicians have to pay attention to comorbid epilepsy in dementia patients with high education, with high VLOM ratio and severe stage.
dc.relation.ispartof urn:issn:1387-2877
dc.title Prevalence, Semiology, and Risk Factors of Epilepsy in Alzheimer's Disease: An Ambulatory EEG Study
dc.type Journal Article
dc.date.updated 2018-09-20T12:47:33Z
dc.language.rfc3066 en
dc.identifier.mtmt 3394937
dc.identifier.wos WOS:000433970800017
dc.identifier.pubmed 29710705
dc.contributor.department SE/AOK/I/Anatómiai, Szövet- és Fejlődéstani Intézet
dc.contributor.department SE/AOK/K/Neurológiai Klinika
dc.contributor.department SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika
dc.contributor.institution Semmelweis Egyetem


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