dc.contributor.author |
Kenézlői, Eszter |
|
dc.contributor.author |
Lakatos K |
|
dc.contributor.author |
Horvath EZ |
|
dc.contributor.author |
Sasvari-Szekely M |
|
dc.contributor.author |
Nemoda, Zsófia |
|
dc.date.accessioned |
2018-10-10T14:38:36Z |
|
dc.date.available |
2018-10-10T14:38:36Z |
|
dc.date.issued |
2018 |
|
dc.identifier |
85051544228 |
|
dc.identifier.citation |
pagination=388-391;
journalVolume=268;
journalTitle=PSYCHIATRY RESEARCH; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6538 |
|
dc.identifier.uri |
doi:10.1016/j.psychres.2018.07.035 |
|
dc.description.abstract |
Our aim was to introduce more homogenous phenotypes for studying genetic variations in the clinically heterogeneous obsessive compulsive disorder (OCD) beside classical case-control analysis. Symptoms were assessed with Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and principle component analysis of the lifetime symptom categories yielded four factors (Cleaning, Obsessive, Compulsive, Sexual). The comparison of serotonin transporter linked polymorphic region (5-HTTLPR) in 102 OCD patients and 223 controls showed an increased L-allele frequency but no difference was observed when rs25531 was included. Intronic variants of the serotonin transporter gene did not show association with either OCD, nor with the obtained factors. © 2018 |
|
dc.relation.ispartof |
urn:issn:0165-1781 |
|
dc.title |
A pilot study of early onset obsessive-compulsive disorder: Symptom dimensions and association analysis with polymorphisms of the serotonin transporter gene |
|
dc.type |
Journal Article |
|
dc.date.updated |
2018-09-28T10:27:33Z |
|
dc.language.rfc3066 |
en |
|
dc.identifier.mtmt |
3424738 |
|
dc.contributor.department |
SE/AOK/I/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet |
|
dc.contributor.department |
SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika |
|
dc.contributor.institution |
Semmelweis Egyetem |
|