A pilot study of early onset obsessive-compulsive disorder: Symptom dimensions and association analysis with polymorphisms of the serotonin transporter gene

dc.contributor.author	Kenézlői, Eszter
dc.contributor.author	Lakatos K
dc.contributor.author	Horvath EZ
dc.contributor.author	Sasvari-Szekely M
dc.contributor.author	Nemoda, Zsófia
dc.date.accessioned	2018-10-10T14:38:36Z
dc.date.available	2018-10-10T14:38:36Z
dc.date.issued	2018
dc.identifier	85051544228
dc.identifier.citation	pagination=388-391; journalVolume=268; journalTitle=PSYCHIATRY RESEARCH;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/6538
dc.identifier.uri	doi:10.1016/j.psychres.2018.07.035
dc.description.abstract	Our aim was to introduce more homogenous phenotypes for studying genetic variations in the clinically heterogeneous obsessive compulsive disorder (OCD) beside classical case-control analysis. Symptoms were assessed with Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and principle component analysis of the lifetime symptom categories yielded four factors (Cleaning, Obsessive, Compulsive, Sexual). The comparison of serotonin transporter linked polymorphic region (5-HTTLPR) in 102 OCD patients and 223 controls showed an increased L-allele frequency but no difference was observed when rs25531 was included. Intronic variants of the serotonin transporter gene did not show association with either OCD, nor with the obtained factors. © 2018
dc.relation.ispartof	urn:issn:0165-1781
dc.title	A pilot study of early onset obsessive-compulsive disorder: Symptom dimensions and association analysis with polymorphisms of the serotonin transporter gene
dc.type	Journal Article
dc.date.updated	2018-09-28T10:27:33Z
dc.language.rfc3066	en
dc.identifier.mtmt	3424738
dc.contributor.department	SE/AOK/I/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet
dc.contributor.department	SE/AOK/K/Pszichiátriai és Pszichoterápiás Klinika
dc.contributor.institution	Semmelweis Egyetem