OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!

dc.contributor.author	Chinopoulos, Christos
dc.date.accessioned	2021-05-28T08:19:34Z
dc.date.available	2021-05-28T08:19:34Z
dc.date.issued	2018
dc.identifier	85047184255
dc.identifier.citation	journalVolume=27;journalIssueNumber=6;journalTitle=CELL METABOLISM;pagerange=1165-1167;journalAbbreviatedTitle=CELL METAB;
dc.identifier.uri	http://repo.lib.semmelweis.hu//handle/123456789/6690
dc.identifier.uri	doi:10.1016/j.cmet.2018.05.010
dc.description.abstract	Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment. Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment. © 2018 Elsevier Inc.
dc.format.extent	1165-1167
dc.relation.ispartof	urn:issn:1550-4131
dc.title	OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!
dc.type	Journal Article
dc.date.updated	2019-01-28T14:08:18Z
dc.language.rfc3066	en
dc.rights.holder	NULL
dc.identifier.mtmt	3382132
dc.identifier.wos	000434480000005
dc.identifier.wos	WOS:000434480000005
dc.identifier.pubmed	29874564
dc.contributor.department	SE/AOK/I/Orvosi Biokémiai Intézet
dc.contributor.institution	Semmelweis Egyetem