dc.contributor.author |
Bene, László |
|
dc.contributor.author |
Falus, András |
|
dc.contributor.author |
Baffy, N |
|
dc.contributor.author |
Fülöp, András Kristóf |
|
dc.date.accessioned |
2021-12-10T10:20:39Z |
|
dc.date.available |
2021-12-10T10:20:39Z |
|
dc.date.issued |
2011 |
|
dc.identifier |
80052723769 |
|
dc.identifier.citation |
journalVolume=17;journalIssueNumber=3;journalTitle=PATHOLOGY AND ONCOLOGY RESEARCH;pagerange=463-472;journalAbbreviatedTitle=PATHOL ONCOL RES; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6701 |
|
dc.identifier.uri |
doi:10.1007/s12253-011-9397-4 |
|
dc.description.abstract |
The factors involved in the pathogenesis of Crohn's disease and ulcerative colitis, the two major types of inflammatory bowel disease (IBD) are summarized. Intestinal antigens composed of bacterial flora along with antigen presentation and impaired mucosal barrier have an important role in the initiation of IBD. The bacterial community may be modified by the use of antibiotics and probiotics. The dentritic cells recognize the antigens by cell surface Toll like receptor and the cytoplasmic CARD/NOD system. The balance between Th1/Th2/Th17 cell populations being the source of a variety of cytokines regulates the inflammatory mechanisms and the clearance of microbes. The intracellular killing and digestion, including autophagy, are important in the protection against microbes and their toxins. The homing process determines the location and distribution of the immune cells along the gut. All these players are potential targets of pharmacological manipulation of disease status. |
|
dc.format.extent |
463-472 |
|
dc.relation.ispartof |
urn:issn:1219-4956; 1532-2807 |
|
dc.title |
Cellular and molecular mechanisms in the two major forms of inflammatory bowel disease |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-01-29T14:27:19Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
1769908 |
|
dc.identifier.wos |
000294067800003 |
|
dc.identifier.pubmed |
21681604 |
|
dc.contributor.department |
MTA TKI/MTA-SE Gyulladásbiológiai és Immungenomikai Kutatócsoport (2006-ig: MTA-SE Molekuláris Immunológiai Kutatócsoport) |
|
dc.contributor.department |
SE/AOK/I/Genetikai, Sejt- és Immunbiológiai Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|