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dc.contributor.author Hornyák, István
dc.contributor.author Edit Madácsi
dc.contributor.author Pálma Kalugyer
dc.contributor.author Vácz, Gabriella
dc.contributor.author Horváthy, Dénes
dc.contributor.author Szendrői, Miklós
dc.contributor.author Lacza, Zsombor
dc.date.accessioned 2014-12-07T16:42:46Z
dc.date.available 2014-12-07T16:42:46Z
dc.date.issued 2014
dc.identifier.citation pagination=459867;journalVolume=2014;journalTitle=BIOMED RESEARCH INTERNATIONAL; hu
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/673
dc.identifier.uri doi:10.1155/2014/459867
dc.description.abstract Theuse of bone allografts is contraindicated in septic revision surgery due to the high risk of graft reinfection.Antibiotic release from the graft may solve the problem and these combinations can theoretically be used for prevention or even therapy of infection.The present study investigated whether amoxicillin, ciprofloxacin, and vancomycin alone or in combination with chitosan or alginate are suitable for short-term or long-term bone coating. Human bone allografts were prepared from femoral head and lyophilized. Antibiotic coating was achieved by incubating the grafts in antibiotic solution and freeze-drying again. Two biopolymers chitosan and alginate were used for creating sustained-release implantable coatings and the drug release profile was characterized in vitro by spectrophotometry. Using lyophilization with or without chitosan only resulted in short-term release that lasted up to 48 hours. Alginate coating enabled a sustained release that lasted for 8 days with amoxicillin, 28 days with ciprofloxacin coating, and 50 days with vancomycin coating. Using only implantable biodegradable allograft and polymers, a sustained release of antibiotics was achieved with ciprofloxacin and vancomycin for several weeks. Since the calculated daily release of the antibiotic was lower than the recommended IV dose, the calcium alginate coated bone graft can support endoprosthesis revision surgery.
dc.relation.ispartof urn:issn:2314-6133
dc.title Increased release time of antibiotics from bone allografts through a novel biodegradable coating hu
dc.type Journal Article hu
dc.date.updated 2014-12-07T16:40:52Z
dc.language.rfc3066 en hu
dc.identifier.mtmt 2702189
dc.identifier.wos 000338064500001
dc.contributor.department SE/ÁOK/I/Klinikai Kísérleti Kutató- és Humán Élettani Intézet
dc.contributor.institution Semmelweis Egyetem


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