Show simple item record Zilhão NR Padmanabhuni SS Pagliaroli, Luca Barta, Csaba BIOS Consortium Smit DJA Cath D Nivard MG Baselmans BML Van Dongen J Paschou P Boomsma DI 2019-04-15T08:10:07Z 2019-04-15T08:10:07Z 2015
dc.identifier 84952870478
dc.identifier.citation journalVolume=18;journalIssueNumber=6;journalTitle=TWIN RESEARCH AND HUMAN GENETICS;pagerange=699-709;journalAbbreviatedTitle=TWIN RES HUM GENET;
dc.identifier.uri doi:10.1017/thg.2015.72
dc.description.abstract Tic disorders are moderately heritable common psychiatric disorders that can be highly troubling, both in childhood and in adulthood. In this study, we report results obtained in the first epigenome-wide association study (EWAS) of tic disorders. The subjects are participants in surveys at the Netherlands Twin Register (NTR) and the NTR biobank project. Tic disorders were measured with a self-report version of the Yale Global Tic Severity Scale Abbreviated version (YGTSS-ABBR), included in the 8th wave NTR data collection (2008). DNA methylation data consisted of 411,169 autosomal methylation sites assessed by the Illumina Infinium HumanMethylation450 BeadChip Kit (HM450k array). Phenotype and DNA methylation data were available in 1,678 subjects (mean age = 41.5). No probes reached genome-wide significance (p < 1.2 × 10-7). The strongest associated probe was cg15583738, located in an intergenic region on chromosome 8 (p = 1.98 × 10-6). Several of the top ranking probes (p < 1 × 10-4) were in or nearby genes previously associated with neurological disorders (e.g., GABBRI, BLM, and ADAM10), warranting their further investigation in relation to tic disorders. The top significantly enriched gene ontology (GO) terms among higher ranking methylation sites included anatomical structure morphogenesis (GO:0009653, p = 4.6 × 10-15) developmental process (GO:0032502, p = 2.96 × 10-12), and cellular developmental process (GO:0048869, p = 1.96 × 10-12). Overall, these results provide a first insight into the epigenetic mechanisms of tic disorders. This first study assesses the role of DNA methylation in tic disorders, and it lays the foundations for future work aiming to unravel the biological mechanisms underlying the architecture of this disorder. Copyright © The Author(s) 2015.
dc.format.extent 699-709
dc.relation.ispartof urn:issn:1832-4274
dc.title Epigenome-Wide Association Study of Tic Disorders
dc.type Journal Article 2019-02-27T12:29:49Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 3002116
dc.identifier.wos 000367159000009
dc.identifier.pubmed 26499864
dc.contributor.department SE/AOK/I/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet
dc.contributor.institution Semmelweis Egyetem

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