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dc.contributor.author Mandl, József
dc.contributor.author Bánhegyi, Gábor
dc.date.accessioned 2021-10-11T08:30:07Z
dc.date.available 2021-10-11T08:30:07Z
dc.date.issued 2018
dc.identifier 85049570904
dc.identifier.citation journalVolume=24;journalIssueNumber=4;journalTitle=PATHOLOGY AND ONCOLOGY RESEARCH;pagerange=821-826;journalAbbreviatedTitle=PATHOL ONCOL RES;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/6805
dc.identifier.uri doi:10.1007/s12253-018-0446-0
dc.description.abstract Glycogen particle is an intracellular organelle, which serves as a carbohydrate reserve in various cells. The function of glycogen is not entirely known in several cell types. Glycogen can be mobilized for different purposes, which can be related to cellular metabolic needs, intracellular redox state, metabolic state of the whole organism depending on regulatory aspects and also on cell functions. Essentially there are two different ways of glycogen degradation localized in different cellular organelles: glycogenolysis or lysosomal breakdown by acid alpha-glucosidase. While glycogenolysis occurs in glycogen particles connected to endoplasmic reticulum membrane, glycogen particles can be also combined with phagophores forming autophagosomes. A subdomain of the endoplasmic reticulum membrane - omegasomes - are the sites for phagophore formation. Thus, three organelles, the endoplasmic reticulum, the phagophore and the glycogen particle forms a triangle in which glycogen degradation occurs. The physiological significance, molecular logic and regulation of the two different catabolic paths are summarized and discussed with special aspect on the role of glycogen particles in intracellular organelle homeostasis and on molecular pathology of the cell. Pathological aspects and some diseases connected to the two different degradation pathways of glycogen particles are also detailed.
dc.format.extent 821-826
dc.relation.ispartof urn:issn:1219-4956; 1532-2807
dc.title The ER - Glycogen Particle - Phagophore Triangle: A Hub Connecting Glycogenolysis and Glycophagy?
dc.type Journal Article
dc.date.updated 2019-02-27T15:40:13Z
dc.language.rfc3066 en
dc.rights.holder NULL
dc.identifier.mtmt 3394372
dc.identifier.wos 000443977800013
dc.identifier.pubmed 29981013
dc.contributor.department SE/AOK/I/Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézet
dc.contributor.institution Semmelweis Egyetem


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