dc.contributor.author |
Csépányi-Kömi, Roland |
|
dc.contributor.author |
Pásztor M |
|
dc.contributor.author |
Bartos, Balázs Ádám |
|
dc.contributor.author |
Ligeti, Erzsébet |
|
dc.date.accessioned |
2019-06-19T13:36:30Z |
|
dc.date.available |
2019-06-19T13:36:30Z |
|
dc.date.issued |
2018 |
|
dc.identifier |
85052511016 |
|
dc.identifier.citation |
journalVolume=48;journalIssueNumber=Suppl. 2;pagination=e12993, pages: 7;journalTitle=EUROPEAN JOURNAL OF CLINICAL INVESTIGATION;journalAbbreviatedTitle=EUR J CLIN INVEST; |
|
dc.identifier.uri |
http://repo.lib.semmelweis.hu//handle/123456789/6820 |
|
dc.identifier.uri |
doi:10.1111/eci.12993 |
|
dc.description.abstract |
Background: GTPase-activating proteins (GAPs) accelerate the rate of hydrolysis of GTP bound to small GTPases, thereby limiting the prevalence and concentration of the active, GTP-bound form of these proteins. The large number of potential GAPs acting on members of the Rho family of small GTPases raises the question of specificity or redundancy. Results: In this review, we summarize experimental data obtained on the role of Rho family GAPs in neutrophils, highlight cases where more than one GAP is involved in a physiological function and show examples that GAPs can be involved not only in termination but also in initiation of cellular processes. We demonstrate that the expression-level regulation of GAPs may also occur in short-living cells such as neutrophils. Finally, we provide insight into the existence and structure of molecular complexes in which Rho family GAPs are involved. Conclusion: GAPs play more complex and varied roles than being simple terminators of cellular processes. © 2018 Stichting European Society for Clinical Investigation Journal Foundation |
|
dc.relation.ispartof |
urn:issn:0014-2972 |
|
dc.title |
The neglected terminators: Rho family GAPs in neutrophils |
|
dc.type |
Journal Article |
|
dc.date.updated |
2019-03-01T14:51:20Z |
|
dc.language.rfc3066 |
en |
|
dc.rights.holder |
NULL |
|
dc.identifier.mtmt |
3424321 |
|
dc.contributor.department |
SE/AOK/I/Élettani Intézet |
|
dc.contributor.institution |
Semmelweis Egyetem |
|