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dc.contributor.author Majoros Attila
dc.contributor.author Szász Attila Marcell
dc.contributor.author Nyirády Péter
dc.contributor.author Székely Eszter
dc.contributor.author Riesz Péter
dc.contributor.author Szendrői Attila
dc.contributor.author Keszthelyi Attila
dc.contributor.author Kulka Janina
dc.contributor.author Romics Imre
dc.date.accessioned 2014-12-09T08:30:59Z
dc.date.available 2014-12-09T08:30:59Z
dc.date.issued 2014
dc.identifier.citation pagination=371-377; journalVolume=46; journalIssueNumber=2; journalTitle=INTERNATIONAL UROLOGY AND NEPHROLOGY;
dc.identifier.uri http://repo.lib.semmelweis.hu//handle/123456789/688
dc.identifier.uri doi:10.1007/s11255-013-0538-4
dc.description.abstract PURPOSE: The main objective of this retrospective study was to evaluate the influence of pathological experience in histological examination of prostate cancer (PCa) on preoperative understaging (UNS), undergrading (UNG), and upgrading (UPG). METHODS: Histopathological data of prostate biopsy (PB) and radical prostatectomy (RP) specimens of patients undergoing subsequent radical prostatectomy (n = 430) in our center were compared. Histological diagnoses of PB were provided either by corresponding academic pathology institute (Group 1: 322 patients) or by external (nonacademic) departments which had a lower number (</=100/year) of PCa histopathological evaluations (Group 2 108 patients). The rate of UNG, UPG, and UNS in both groups and also the effects of institutional learning curve were analyzed in terms of grading and staging. RESULTS: Significant difference was detected between Group 1 and Group 2 in average preoperative Gleason score (GS) values and in the rate of well, moderately, and poorly differentiated cancers as well. There was also a significant difference in the rate of UNG (29.1 vs. 56.5 %, p < 0.0001). The mean preoperative and postoperative GS in Group 1 was significantly lower in the first 50 than in the last 50 patients, but the rates of UNG, UPG, and UNS did not differ significantly between the groups. CONCLUSIONS: The experience of pathologists has direct influence on grading concordance and on UNG and UPG, between PB and RP specimen; however, it has no significant effect on complete preoperative understaging. The bigger pathological experience improves the sensitivity of the histological diagnostic process.
dc.relation.ispartof urn:issn:0301-1623
dc.title The influence of expertise of the surgical pathologist to undergrading, upgrading, and understaging of prostate cancer in patients undergoing subsequent radical prostatectomy.
dc.type Journal Article
dc.date.updated 2014-12-08T13:57:40Z
dc.language.rfc3066 en
dc.identifier.mtmt 2409169
dc.identifier.pubmed 23990495
dc.contributor.department SE/ÁOK/K/Urológiai Klinika
dc.contributor.department SE/ÁOK/I/II. Sz. Patológiai Intézet
dc.contributor.institution Semmelweis Egyetem


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